ethyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate

Base Information

• Chemical Name: ethyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate
• CAS No.: 1606168-21-1
• Molecular Formula: C₂₁H₂₃N₄O₅P
• Molecular Weight: 442.411
• Mol file: 1606168-21-1.mol

Synonyms:ethyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate

Chemical Property of ethyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate

There total 3 articles about ethyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenol (1606168-14-2) + ethyl ethylphosphonochloridate (5284-10-6) → ethyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate (1606168-21-1)

Guidance literature:

2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenol; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

ethyl ethylphosphonochloridate; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm401742r

Reference yield:

4-chloro-6-(3-nitrophenyl)-pyrimidine (915069-51-1) → ethyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate (1606168-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; isopropyl alcohol;

DOI:10.1021/jm401742r

Reference yield:

amino-4 hydroxy-2 toluene (2835-95-2) → ethyl 2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl ethylphosphonate (1606168-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; isopropyl alcohol;

DOI:10.1021/jm401742r

upstream raw materials:

4-chloro-6-(3-nitrophenyl)-pyrimidine

amino-4 hydroxy-2 toluene

2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenol

ethyl ethylphosphonochloridate

Downstream raw materials:

5-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}-2-methylphenyl ethyl ethylphosphonate

Refernces