methyl (2S,3S)-2-[(2S,3S)-{(S)-1-[(S)-2-(2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}thiazol-4-ylcarbonylamino)-3-phenylpropanoyl]pyrrolidin-2-ylcarbonylamino}-3-methylpentanoylamino]-3-hydroxybutanoate

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Chemical Name:methyl (2S,3S)-2-[(2S,3S)-{(S)-1-[(S)-2-(2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}thiazol-4-ylcarbonylamino)-3-phenylpropanoyl]pyrrolidin-2-ylcarbonylamino}-3-methylpentanoylamino]-3-hydroxybutanoate
CAS No.:442682-31-7
Molecular Formula:C₄₇H₆₃N₇O₁₀S
Molecular Weight:918.124
Hs Code.:

methyl (2S,3S)-2-[(2S,3S)-{(S)-1-[(S)-2-(2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}thiazol-4-ylcarbonylamino)-3-phenylpropanoyl]pyrrolidin-2-ylcarbonylamino}-3-methylpentanoylamino]-3-hydroxybutanoate

Synonyms:methyl (2S,3S)-2-[(2S,3S)-{(S)-1-[(S)-2-(2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}thiazol-4-ylcarbonylamino)-3-phenylpropanoyl]pyrrolidin-2-ylcarbonylamino}-3-methylpentanoylamino]-3-hydroxybutanoate

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Chemical Property of methyl (2S,3S)-2-[(2S,3S)-{(S)-1-[(S)-2-(2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}thiazol-4-ylcarbonylamino)-3-phenylpropanoyl]pyrrolidin-2-ylcarbonylamino}-3-methylpentanoylamino]-3-hydroxybutanoate

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Technology Process of methyl (2S,3S)-2-[(2S,3S)-{(S)-1-[(S)-2-(2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}thiazol-4-ylcarbonylamino)-3-phenylpropanoyl]pyrrolidin-2-ylcarbonylamino}-3-methylpentanoylamino]-3-hydroxybutanoate

There total 5 articles about methyl (2S,3S)-2-[(2S,3S)-{(S)-1-[(S)-2-(2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}thiazol-4-ylcarbonylamino)-3-phenylpropanoyl]pyrrolidin-2-ylcarbonylamino}-3-methylpentanoylamino]-3-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: (2S,3S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-hydroxy-butyric acid methyl ester; compound with trifluoro-methanesulfonic acid

: 442682-30-6
(S)-1-[(S)-2-({2-[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidin-2-yl]-thiazole-4-carbonyl}-amino)-3-phenyl-propionyl]-pyrrolidine-2-carboxylic acid

: 442682-31-7
methyl (2S,3S)-2-[(2S,3S)-{(S)-1-[(S)-2-(2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}thiazol-4-ylcarbonylamino)-3-phenylpropanoyl]pyrrolidin-2-ylcarbonylamino}-3-methylpentanoylamino]-3-hydroxybutanoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 2.5h;
DOI:10.1246/bcsj.75.847

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 442682-31-7
methyl (2S,3S)-2-[(2S,3S)-{(S)-1-[(S)-2-(2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}thiazol-4-ylcarbonylamino)-3-phenylpropanoyl]pyrrolidin-2-ylcarbonylamino}-3-methylpentanoylamino]-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / [benzotriazol-1-yloxy-tris(dimethylamino)phosphonium]PF₆; triethylamine / dimethylformamide / 0 - 20 °C

2: 100 percent / NaOH / H₂O; methanol / 2 h / 0 °C

3: 97 percent / [benzotriazol-1-yloxy-tris(dimethylamino)phosphonium]PF₆; triethylamine / dimethylformamide / 0 - 20 °C

4: 94 percent / NaOH / H₂O; methanol / 1.5 h / 0 °C

5: 54 percent / [benzotriazol-1-yloxy-tris(dimethylamino)phosphonium]PF₆; triethylamine / dimethylformamide / 2.5 h / 0 °C

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.75.847

Reference yield:

: 347191-35-9
methyl 2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}-thiazole-4-carboxylate

: 442682-31-7
methyl (2S,3S)-2-[(2S,3S)-{(S)-1-[(S)-2-(2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}thiazol-4-ylcarbonylamino)-3-phenylpropanoyl]pyrrolidin-2-ylcarbonylamino}-3-methylpentanoylamino]-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / NaOH / H₂O; methanol / 2 h / 0 °C

2: 97 percent / [benzotriazol-1-yloxy-tris(dimethylamino)phosphonium]PF₆; triethylamine / dimethylformamide / 0 - 20 °C

3: 94 percent / NaOH / H₂O; methanol / 1.5 h / 0 °C

4: 54 percent / [benzotriazol-1-yloxy-tris(dimethylamino)phosphonium]PF₆; triethylamine / dimethylformamide / 2.5 h / 0 °C

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.75.847