(3E)-1-[(2E)-3-(N-{(1R)-2-(3,3-dimethyl-2-oxoazetidin-1-yl)-1-[(4-methoxyphenyl)methyl]-2-oxoethyl}carbamoyl)prop-2-enyl]-(1S,2R)-2-methyl-4-phenylbut-3-enyl (2S)-2-hydroxy-4-methylpentanoate

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Chemical Name:(3E)-1-[(2E)-3-(N-{(1R)-2-(3,3-dimethyl-2-oxoazetidin-1-yl)-1-[(4-methoxyphenyl)methyl]-2-oxoethyl}carbamoyl)prop-2-enyl]-(1S,2R)-2-methyl-4-phenylbut-3-enyl (2S)-2-hydroxy-4-methylpentanoate
CAS No.:644989-79-7
Molecular Formula:C₃₆H₄₆N₂O₇
Molecular Weight:618.77
Hs Code.:

(3E)-1-[(2E)-3-(N-{(1R)-2-(3,3-dimethyl-2-oxoazetidin-1-yl)-1-[(4-methoxyphenyl)methyl]-2-oxoethyl}carbamoyl)prop-2-enyl]-(1S,2R)-2-methyl-4-phenylbut-3-enyl (2S)-2-hydroxy-4-methylpentanoate

Synonyms:(3E)-1-[(2E)-3-(N-{(1R)-2-(3,3-dimethyl-2-oxoazetidin-1-yl)-1-[(4-methoxyphenyl)methyl]-2-oxoethyl}carbamoyl)prop-2-enyl]-(1S,2R)-2-methyl-4-phenylbut-3-enyl (2S)-2-hydroxy-4-methylpentanoate

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Chemical Property of (3E)-1-[(2E)-3-(N-{(1R)-2-(3,3-dimethyl-2-oxoazetidin-1-yl)-1-[(4-methoxyphenyl)methyl]-2-oxoethyl}carbamoyl)prop-2-enyl]-(1S,2R)-2-methyl-4-phenylbut-3-enyl (2S)-2-hydroxy-4-methylpentanoate

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Technology Process of (3E)-1-[(2E)-3-(N-{(1R)-2-(3,3-dimethyl-2-oxoazetidin-1-yl)-1-[(4-methoxyphenyl)methyl]-2-oxoethyl}carbamoyl)prop-2-enyl]-(1S,2R)-2-methyl-4-phenylbut-3-enyl (2S)-2-hydroxy-4-methylpentanoate

There total 8 articles about (3E)-1-[(2E)-3-(N-{(1R)-2-(3,3-dimethyl-2-oxoazetidin-1-yl)-1-[(4-methoxyphenyl)methyl]-2-oxoethyl}carbamoyl)prop-2-enyl]-(1S,2R)-2-methyl-4-phenylbut-3-enyl (2S)-2-hydroxy-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 644989-75-3
(2E,7E)-(5S,6R)-5-((S)-2-Hydroxy-4-methyl-pentanoyloxy)-6-methyl-8-phenyl-octa-2,7-dienoic acid

: 1-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionyl]-3,3-dimethyl-azetidin-2-one; hydrochloride

: 644989-79-7
(3E)-1-[(2E)-3-(N-{(1R)-2-(3,3-dimethyl-2-oxoazetidin-1-yl)-1-[(4-methoxyphenyl)methyl]-2-oxoethyl}carbamoyl)prop-2-enyl]-(1S,2R)-2-methyl-4-phenylbut-3-enyl (2S)-2-hydroxy-4-methylpentanoate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 4h;
DOI:10.1021/jo0302197

Reference yield:

: 7486-91-1
3,3-dimethyl-2-azetidinone

: 644989-79-7
(3E)-1-[(2E)-3-(N-{(1R)-2-(3,3-dimethyl-2-oxoazetidin-1-yl)-1-[(4-methoxyphenyl)methyl]-2-oxoethyl}carbamoyl)prop-2-enyl]-(1S,2R)-2-methyl-4-phenylbut-3-enyl (2S)-2-hydroxy-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / DIEA; HBTU / acetonitrile / 5 h / 20 °C

2: HCl / dioxane / 4 h / 20 °C

3: 58 percent / DIEA; HBTU / acetonitrile / 4 h / 0 - 20 °C

With hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile;
DOI:10.1021/jo0302197

Reference yield:

: 68856-96-2
N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine

: 644989-79-7
(3E)-1-[(2E)-3-(N-{(1R)-2-(3,3-dimethyl-2-oxoazetidin-1-yl)-1-[(4-methoxyphenyl)methyl]-2-oxoethyl}carbamoyl)prop-2-enyl]-(1S,2R)-2-methyl-4-phenylbut-3-enyl (2S)-2-hydroxy-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / DIEA; HBTU / acetonitrile / 5 h / 20 °C

2: HCl / dioxane / 4 h / 20 °C

3: 58 percent / DIEA; HBTU / acetonitrile / 4 h / 0 - 20 °C

With hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile;
DOI:10.1021/jo0302197