Technology Process of 1-tert-butyl 4-((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 2,2-dimethylsuccinate
There total 17 articles about 1-tert-butyl 4-((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 2,2-dimethylsuccinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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1443467-51-3
(3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)acetyl)-9-hydroxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-2-one
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1443467-52-4
1-tert-butyl 4-((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 2,2-dimethylsuccinate
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1443467-53-5
1-tert-butyl 4-((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((S)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 2,2-dimethylsuccinate
- Guidance literature:
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With
methanol; sodium tetrahydroborate;
at 20 ℃;
for 1h;
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55976-58-4
((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-9-acetoxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-3a-yl)methyl acetate
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1443467-52-4
1-tert-butyl 4-((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 2,2-dimethylsuccinate
- Guidance literature:
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Multi-step reaction with 11 steps
1.1: sodium acetate; sodium dichromate dihydrate / toluene; acetic acid; acetic anhydride / 60 °C
2.1: potassium hydroxide; water / toluene; ethanol / 1 h / 20 °C
2.2: pH 7
3.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
4.1: triethylamine / 20 °C
5.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate; methanol / 0.5 h / -5 - 10 °C
6.1: magnesium sulfate; triethylamine / methanol / 2 h / 20 °C
6.2: 0.5 h
6.3: 1 h / 20 °C
7.1: pyridinium chlorochromate / dichloromethane / 20 °C
8.1: hydrogenchloride / methanol / 45 °C
9.1: triethylamine; sodium cyanoborohydride / methanol; 1,2-dichloro-ethane / 0 - 20 °C
10.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C
11.1: sodium tetrahydroborate; methanol / 1 h / 20 °C
With
hydrogenchloride; methanol; dmap; sodium tetrahydroborate; sodium dichromate dihydrate; nickel(II) chloride hexahydrate; water; sodium acetate; sodium cyanoborohydride; magnesium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; potassium hydroxide;
In
methanol; ethanol; dichloromethane; acetic anhydride; acetic acid; 1,2-dichloro-ethane; toluene;
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139255-65-5
((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-9-acetoxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-3a-yl)methyl acetate
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1443467-52-4
1-tert-butyl 4-((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 2,2-dimethylsuccinate
- Guidance literature:
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Multi-step reaction with 10 steps
1.1: potassium hydroxide; water / toluene; ethanol / 1 h / 20 °C
1.2: pH 7
2.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
3.1: triethylamine / 20 °C
4.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate; methanol / 0.5 h / -5 - 10 °C
5.1: magnesium sulfate; triethylamine / methanol / 2 h / 20 °C
5.2: 0.5 h
5.3: 1 h / 20 °C
6.1: pyridinium chlorochromate / dichloromethane / 20 °C
7.1: hydrogenchloride / methanol / 45 °C
8.1: triethylamine; sodium cyanoborohydride / methanol; 1,2-dichloro-ethane / 0 - 20 °C
9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C
10.1: sodium tetrahydroborate; methanol / 1 h / 20 °C
With
hydrogenchloride; methanol; dmap; sodium tetrahydroborate; nickel(II) chloride hexahydrate; water; sodium cyanoborohydride; magnesium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; potassium hydroxide;
In
methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;