[6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

Base Information

Chemical Name:[6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid
CAS No.:1026051-67-1
Molecular Formula:C₁₆H₁₉N₃O₃
Molecular Weight:301.345
Hs Code.:

[6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2<i>H</i>-pyrazin-1-yl]-acetic acid

Synonyms:[6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

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Chemical Property of [6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

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Technology Process of [6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

There total 4 articles about [6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199296-26-9
(3,5-dichloro-6-methyl-2-oxo-2H-pyrazin-1-yl)acetic acid benzyl ester

: 1026051-67-1
[6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ethyl acetate / 2 h / Heating

2: LiOH / methanol; tetrahydrofuran; H₂O / 15 h

3: 1.) KOH, 2.) H₂ / 2.) 10 percent Pd/C / 1.) H₂O

With potassium hydroxide; lithium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water; ethyl acetate;
DOI:10.1021/jm980368v

Reference yield:

: Benzyl 2-[(1-cyanoethyl)amino]acetate hydrochloride

: 1026051-67-1
[6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 56 percent / 1,2-dichloro-benzene / 15 h / 100 °C

2: ethyl acetate / 2 h / Heating

3: LiOH / methanol; tetrahydrofuran; H₂O / 15 h

4: 1.) KOH, 2.) H₂ / 2.) 10 percent Pd/C / 1.) H₂O

With potassium hydroxide; lithium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water; ethyl acetate; 1,2-dichloro-benzene;
DOI:10.1021/jm980368v

Reference yield:

: 1027892-22-3
[5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid benzyl ester

: 1026051-67-1
[6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: LiOH / methanol; tetrahydrofuran; H₂O / 15 h

2: 1.) KOH, 2.) H₂ / 2.) 10 percent Pd/C / 1.) H₂O

With potassium hydroxide; lithium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm980368v