(rac)-{[3-({4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoropyrimidin-2-yl}amino)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide

Base Information

• Chemical Name: (rac)-{[3-({4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoropyrimidin-2-yl}amino)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide
• CAS No.: 1427314-27-9
• Molecular Formula: C₂₆H₂₁F₂N₅O₂S
• Molecular Weight: 505.548

Synonyms:(rac)-{[3-({4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoropyrimidin-2-yl}amino)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide

Chemical Property of (rac)-{[3-({4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoropyrimidin-2-yl}amino)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide

Chemical Property:

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Technology Process of (rac)-{[3-({4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoropyrimidin-2-yl}amino)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide

There total 4 articles about (rac)-{[3-({4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoropyrimidin-2-yl}amino)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(rac)-[[3-({4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoropyrimidin-2-yl}amino)benzyl](methyl)-λ4-sulfanylidene]-cyanamide (1427316-45-7) → (rac)-{[3-({4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoropyrimidin-2-yl}amino)benzyl](methyl)oxido-λ6-sulfanylidene}cyanamide (1427314-27-9)

Guidance literature:

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; at 0 - 20 ℃;

Reference yield:

4-[2-(benzyloxy)-4-fluorophenyl]-2-chloro-5-fluoropyrimidine (1426215-32-8) → (rac)-{[3-({4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoropyrimidin-2-yl}amino)benzyl](methyl)oxido-λ6-sulfanylidene}cyanamide (1427314-27-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; butan-1-ol / 16 h / 140 °C

2: N-bromophthalimide; potassium tert-butylate / methanol / 4 h / 20 °C

3: potassium carbonate; 3-chloro-benzenecarboperoxoic acid / ethanol / 0 - 20 °C

With hydrogenchloride; N-bromophthalimide; potassium tert-butylate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; methanol; ethanol; butan-1-ol;

Reference yield:

4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoro-N-{3-[(methylsulfanyl)methyl]phenyl}pyrimidin-2-amine (1427315-47-6) → (rac)-{[3-({4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoropyrimidin-2-yl}amino)benzyl](methyl)oxido-λ6-sulfanylidene}cyanamide (1427314-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-bromophthalimide; potassium tert-butylate / methanol / 4 h / 20 °C

2: potassium carbonate; 3-chloro-benzenecarboperoxoic acid / ethanol / 0 - 20 °C

With N-bromophthalimide; potassium tert-butylate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol;

upstream raw materials:

4-[2-(benzyloxy)-4-fluorophenyl]-2-chloro-5-fluoropyrimidine

4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoro-N-{3-[(methylsulfanyl)methyl]phenyl}pyrimidin-2-amine

3-[(methylsulfanyl)methyl]aniline

(rac)-[[3-({4-[2-(benzyloxy)-4-fluorophenyl]-5-fluoropyrimidin-2-yl}amino)benzyl](methyl)-λ⁴-sulfanylidene]-cyanamide

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