(2S)-ethyl 3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanic acid

Base Information

Chemical Name:(2S)-ethyl 3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanic acid
CAS No.:100431-44-5
Molecular Formula:C₁₆H₂₃NO₃S
Molecular Weight:309.43
Hs Code.:

Synonyms:(2S)-ethyl 3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanic acid

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Chemical Property of (2S)-ethyl 3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanic acid

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Technology Process of (2S)-ethyl 3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanic acid

There total 10 articles about (2S)-ethyl 3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100431-42-3
(2RS)-ethyl 3-<<(1R)-1-<(acetylthio)methyl>-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanoate

: 100431-44-5
(2RS)-ethyl 3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanic acid

Guidance literature:: With sodium hydroxide; In methanol; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm00155a027

Reference yield:

: 100431-42-3
(2RS)-ethyl 3-<<(1R)-1-<(acetylthio)methyl>-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanoate

: 100431-44-5
(2S)-ethyl 3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanic acid

: 100431-43-4
(2R)-ethyl 3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanic acid

Guidance literature:: With sodium hydroxide; In methanol; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm00155a027

Reference yield:

: 2985-36-6
2-ethoxycarbonyl-4-methylpentanoic acid

: 100431-44-5
(2RS)-ethyl 3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / triethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CHCl₃; tetrahydrofuran / Ambient temperature

2: 84 percent / acetonitrile / 1 h / 85 °C

3: 1N aq. NaOH / methanol / 2 h / 0 - 20 °C

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform; acetonitrile;
DOI:10.1021/jm00155a027