(S)-2,2,2-trichloro-N-[3-(4-fluorophenyl)-1-(2-hydroxyethyl)allyl]acetamide

Base Information

Chemical Name:(S)-2,2,2-trichloro-N-[3-(4-fluorophenyl)-1-(2-hydroxyethyl)allyl]acetamide
CAS No.:607358-47-4
Molecular Formula:C₁₃H₁₃Cl₃FNO₂
Molecular Weight:340.609
Hs Code.:

Synonyms:(S)-2,2,2-trichloro-N-[3-(4-fluorophenyl)-1-(2-hydroxyethyl)allyl]acetamide

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Chemical Property of (S)-2,2,2-trichloro-N-[3-(4-fluorophenyl)-1-(2-hydroxyethyl)allyl]acetamide

Chemical Property:

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Technology Process of (S)-2,2,2-trichloro-N-[3-(4-fluorophenyl)-1-(2-hydroxyethyl)allyl]acetamide

There total 4 articles about (S)-2,2,2-trichloro-N-[3-(4-fluorophenyl)-1-(2-hydroxyethyl)allyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607358-35-0
(S)-2,2,2-trichloro-N-[3-(4-fluorophenyl)-1-(2-trityloxyethyl)allyl]acetamide

: 607358-47-4
(S)-2,2,2-trichloro-N-[3-(4-fluorophenyl)-1-(2-hydroxyethyl)allyl]acetamide

Guidance literature:: With diethylaluminium chloride; In dichloromethane; toluene; at 20 ℃; for 0.333333h;
DOI:10.1021/ja035213d

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 607358-47-4
(S)-2,2,2-trichloro-N-[3-(4-fluorophenyl)-1-(2-hydroxyethyl)allyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Cy₂BH / toluene / 0.5 h / 20 °C

1.2: (-)-MIB; Et₂Zn / toluene / 3.5 h / -30 °C

2.1: DBU / diethyl ether / -5 - 20 °C

3.1: 26 mg / toluene / 17 h / Heating

4.1: Et₂AlCl / CH₂Cl₂; toluene / 0.33 h / 20 °C

With bis(cyclohexanyl)borane; diethylaluminium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; dichloromethane; toluene; 3.1: Overman rearrangement;
DOI:10.1021/ja035213d

Reference yield:

: 607358-19-0
(S)-1-(4-fluorophenyl)-5-trityloxypent-2-en-1-ol

: 607358-47-4
(S)-2,2,2-trichloro-N-[3-(4-fluorophenyl)-1-(2-hydroxyethyl)allyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: DBU / diethyl ether / -5 - 20 °C

2: 26 mg / toluene / 17 h / Heating

3: Et₂AlCl / CH₂Cl₂; toluene / 0.33 h / 20 °C

With diethylaluminium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; dichloromethane; toluene; 2: Overman rearrangement;
DOI:10.1021/ja035213d