3-(4-methylpiperazin-1-yl)quinolin-5-yl 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

Base Information

Chemical Name:3-(4-methylpiperazin-1-yl)quinolin-5-yl 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate
CAS No.:1268264-32-9
Molecular Formula:C₂₆H₂₃FN₄O₃
Molecular Weight:458.492
Hs Code.:

Synonyms:3-(4-methylpiperazin-1-yl)quinolin-5-yl 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

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Chemical Property of 3-(4-methylpiperazin-1-yl)quinolin-5-yl 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

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Technology Process of 3-(4-methylpiperazin-1-yl)quinolin-5-yl 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

There total 5 articles about 3-(4-methylpiperazin-1-yl)quinolin-5-yl 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 868171-67-9
1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

: 1268264-40-9
3-(4-methylpiperazin-1-yl)-5-hydroxyquinoline

: 1268264-32-9
3-(4-methylpiperazin-1-yl)quinolin-5-yl 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm101340q

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1268264-32-9
3-(4-methylpiperazin-1-yl)quinolin-5-yl 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 8 h / 110 °C / Inert atmosphere

2.1: iron; ammonium chloride / ethanol; water / Reflux

3.1: sulfuric acid; acetic acid; sodium nitrite / water / 0.5 h / 0 °C

3.2: 0.08 h / Reflux

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; iron; ammonium chloride; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Buchwald-Hartwig coupling / 3.1: Sandmeyer reaction / 3.2: Sandmeyer reaction;
DOI:10.1021/jm101340q

Reference yield:

: 1268264-38-5
C₁₄H₁₆N₄O₂

: 1268264-32-9
3-(4-methylpiperazin-1-yl)quinolin-5-yl 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: iron; ammonium chloride / ethanol; water / Reflux

2.1: sulfuric acid; acetic acid; sodium nitrite / water / 0.5 h / 0 °C

2.2: 0.08 h / Reflux

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere

With sulfuric acid; iron; ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; 2.1: Sandmeyer reaction / 2.2: Sandmeyer reaction;
DOI:10.1021/jm101340q