6-DIMETHYLAMINO-2-NAPHTHALDEHYDE

Base Information

• Chemical Name: 6-DIMETHYLAMINO-2-NAPHTHALDEHYDE
• CAS No.: 173471-71-1
• Molecular Formula: C13H13 N O
• Molecular Weight: 199.252
• Hs Code.: 2922399090
• Mol file: 173471-71-1.mol

Synonyms:6-(Dimethylamino)-2-naphthaldehyde;6-Dimethylamino-2-naphthalenecarboxaldehyde

Chemical Property of 6-DIMETHYLAMINO-2-NAPHTHALDEHYDE

Chemical Property:

• Vapor Pressure: 1.11E-05mmHg at 25°C
• Refractive Index: 1.676
• Boiling Point: 370.4°Cat760mmHg
• PKA: 3.55±0.40(Predicted)
• Flash Point: 151.4°C
• PSA: 20.31000
• Density: 1.15g/cm³
• LogP: 2.71830
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-(Dimethylamino)-2-naphthaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-DIMETHYLAMINO-2-NAPHTHALDEHYDE

There total 12 articles about 6-DIMETHYLAMINO-2-NAPHTHALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

6?bromo?N,N?dimethylnaphthalen?2?amine (5043-03-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6‐(dimethylamino)‐2-naphthaldehyde (173471-71-1)

Guidance literature:

6?bromo?N,N?dimethylnaphthalen?2?amine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at 20 ℃; for 0.25h;

Reference yield: 84.0%

→ 6‐(dimethylamino)‐2-naphthaldehyde (173471-71-1)

Guidance literature:

Reference yield: 75.0%

2-(dimethylamino)-6-naphthonitrile (5043-04-9) → 6‐(dimethylamino)‐2-naphthaldehyde (173471-71-1)

Guidance literature:

With diisobutylaluminium hydride; In hexane; toluene; at -78 - 20 ℃; for 4.5h; Inert atmosphere;

DOI:10.1039/c9tb00576e

upstream raw materials:

6-(dimethylamino)naphthalene-2-methanol

6-bromo-naphthalen-2-ol

6-(bis(ethylthio)methyl)-2-dimethylaminonaphthalene

6?bromo?N,N?dimethylnaphthalen?2?amine

Downstream raw materials:

2-((2E,4E)-5-(6-(dimethylamino)naphthalen-2-yl)penta-2,4-dien-1-ylidene)malononitrile

6-(dimethylamino)naphthalene-2-methanol

Refernces

• 1、 Zhan, Zixuan,Liu, Rui,Chai, Li,Dai, Yongcheng,Lv, Yi. "Visualization of Lung Inflammation to Pulmonary Fibrosis via Peroxynitrite Fluctuation". . p. 11461 - 11466. Retrieved 2019.
• 2、 Liu, Xianjun,Xiang, Meihao,Tong, Zongxuan,Luo, Fengyan,Chen, Wen,Liu, Feng,Wang, Fenglin,Yu, Ru-Qin,Jiang, Jian-Hui. "Activatable Fluorescence Probe via Self-Immolative Intramolecular Cyclization for Histone Deacetylase Imaging in Live Cells and Tissues". . p. 5534 - 5539. Retrieved 2018.
• 3、 An, Jusung,Jangili, Paramesh,Lim, Sungsu,Kim, Yun Kyung,Verwilst, Peter,Kim, Jong Seung. "Multichromatic fluorescence towards aberrant proteinaceous aggregates utilizing benzimidazole-based ICT fluorophores". . p. 205 - 215. Retrieved 2021/07/20.
• 4、 Chen, Ding,Fang, Haixiao,Li, Lin,Lim, Kah-Leong,Lu, Xiaomei,Qu, Yunwei,Shi, Riri,Wu, Qiong,Yang, Xuekang,Zhang, Cheng-Wu. "Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging". supporting information. p. 11260 - 11263. Retrieved 2021/11/09.