N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-(benzyloxy)acetamide

Base Information

Chemical Name:N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-(benzyloxy)acetamide
CAS No.:1000334-11-1
Molecular Formula:C₂₂H₂₆N₂O₄
Molecular Weight:382.459
Hs Code.:

Synonyms:N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-(benzyloxy)acetamide

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Chemical Property of N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-(benzyloxy)acetamide

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Technology Process of N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-(benzyloxy)acetamide

There total 14 articles about N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-(benzyloxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1000334-09-7
N-[2-(6-amino-7-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]acetamide hydrochloride

: 19810-31-2
Benzyloxyacetyl chloride

: 1000334-11-1
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-(benzyloxy)acetamide

Guidance literature:: With pyridine; at 0 ℃; for 0.25h;

Reference yield:

: 90792-61-3
4-bromo-7-hydroxy-6-nitroindan-1-one

: 1000334-11-1
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-(benzyloxy)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 40 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

2.2: 0.5 h

3.1: hydrogen; triethylamine / palladium 10% on activated carbon / ethyl acetate / 1.5 h / 20 °C

4.1: ammonia; hydrogen / cobalt / ethanol / 2 h / 20 °C

5.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

7.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

8.1: pyridine / 0.25 h / 0 °C

With pyridine; ammonia; hydrogen; boron tribromide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium 10% on activated carbon; cobalt; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1000334-03-1
4-bromo-7-methoxy-6-nitroindan-1-one

: 1000334-11-1
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-2-(benzyloxy)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 0.5 h

2.1: hydrogen; triethylamine / palladium 10% on activated carbon / ethyl acetate / 1.5 h / 20 °C

3.1: ammonia; hydrogen / cobalt / ethanol / 2 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

6.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

7.1: pyridine / 0.25 h / 0 °C

With pyridine; ammonia; hydrogen; boron tribromide; sodium hydride; triethylamine; palladium 10% on activated carbon; cobalt; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;