(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one

Base Information

Chemical Name:(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
CAS No.:1360109-87-0
Molecular Formula:C₂₃H₄₀O₄Si
Molecular Weight:408.654
Hs Code.:

Synonyms:(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one

Suppliers and Price of (5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one

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Technology Process of (5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one

There total 20 articles about (5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1360109-86-9
(S)-1-(4-(benzyloxy)-3-methoxyphenyl)-5-(tert-butyldimethylsilyloxy)dec-1-yn-3-one

: 1360109-87-0
(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one

Guidance literature:: With hydrogen; palladium(II) hydroxide; In benzene; at 20 ℃; for 5h;
DOI:10.1016/j.tetasy.2011.11.010

Reference yield: 92.0%

: (5S)-1-[4-(benzyloxy)-3-methoxyphenyl]-5-{[tert-butyl(dimethyl)silyl]oxy}decan-3-one

: 1360109-87-0
(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 5h; under 2068.65 Torr;
DOI:10.1002/hlca.201400393

Reference yield:

: C₁₅H₃₄O₃Si

: 1360109-87-0
(5S)-5-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-hydroxy-3-methoxyphenyl)decan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium periodate / tetrahydrofuran; water / 1 h

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 4 h / -78 - 20 °C

3.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: hydrogen; palladium(II) hydroxide / benzene / 5 h / 20 °C

With sodium periodate; n-butyllithium; hydrogen; palladium(II) hydroxide; dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; hexane; dichloromethane; water; benzene;
DOI:10.1016/j.tetasy.2011.11.010