methyl (2S)-2-{[(R)-{4-[1-(2-methoxyethyl)piperidin-3-yl]phenyl}(phenyl)methyl]oxy}-4-methylpentanoate

Base Information

Chemical Name:methyl (2S)-2-{[(R)-{4-[1-(2-methoxyethyl)piperidin-3-yl]phenyl}(phenyl)methyl]oxy}-4-methylpentanoate
CAS No.:672328-84-6
Molecular Formula:C₂₈H₃₉NO₄
Molecular Weight:453.622
Hs Code.:

Synonyms:methyl (2S)-2-{[(R)-{4-[1-(2-methoxyethyl)piperidin-3-yl]phenyl}(phenyl)methyl]oxy}-4-methylpentanoate

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Chemical Property of methyl (2S)-2-{[(R)-{4-[1-(2-methoxyethyl)piperidin-3-yl]phenyl}(phenyl)methyl]oxy}-4-methylpentanoate

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Technology Process of methyl (2S)-2-{[(R)-{4-[1-(2-methoxyethyl)piperidin-3-yl]phenyl}(phenyl)methyl]oxy}-4-methylpentanoate

There total 8 articles about methyl (2S)-2-{[(R)-{4-[1-(2-methoxyethyl)piperidin-3-yl]phenyl}(phenyl)methyl]oxy}-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 672328-83-5
3-{4-[(R)-{[(1S)-1-(methoxycarbonyl)-3-methylbutyl]oxy}(phenyl)methyl]phenyl}-1-(2-methoxyethyl) pyridinium bromide

: 672328-84-6
methyl (2S)-2-{[(R)-{4-[1-(2-methoxyethyl)piperidin-3-yl]phenyl}(phenyl)methyl]oxy}-4-methylpentanoate

Guidance literature:: With hydrogen; acetic acid; platinum(IV) oxide; In ethanol; for 18h; under 3102.97 Torr;

Reference yield:

: 672328-09-5
(5S)-2-(4-bromophenyl)-5-isobutyl-1,3-dioxolan-4-one

: 672328-84-6
methyl (2S)-2-{[(R)-{4-[1-(2-methoxyethyl)piperidin-3-yl]phenyl}(phenyl)methyl]oxy}-4-methylpentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: zinc(II) chloride / diethyl ether / 2 h / 0 °C

2: acetic acid / diethyl ether; methanol / 0 °C

3: sodium carbonate / [1,1'- bis(diphenylphosphino)ferrocene]dichloropalladium (II) complex with dichloromethane (1:1) / N,N-dimethyl-formamide / 2.5 h / 85 °C

4: acetonitrile / 18 h / 120 °C

5: hydrogen; acetic acid / platinum(IV) oxide / ethanol / 18 h / 3102.97 Torr

With hydrogen; sodium carbonate; acetic acid; zinc(II) chloride; platinum(IV) oxide; In methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 672328-74-4
methyl (2S)-2-{[(R)-(4-bromophenyl)(phenyl)methyl]oxy}-4-methylpentanoate

: 672328-84-6
methyl (2S)-2-{[(R)-{4-[1-(2-methoxyethyl)piperidin-3-yl]phenyl}(phenyl)methyl]oxy}-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / [1,1'- bis(diphenylphosphino)ferrocene]dichloropalladium (II) complex with dichloromethane (1:1) / N,N-dimethyl-formamide / 2.5 h / 85 °C

2: acetonitrile / 18 h / 120 °C

3: hydrogen; acetic acid / platinum(IV) oxide / ethanol / 18 h / 3102.97 Torr

With hydrogen; sodium carbonate; acetic acid; platinum(IV) oxide; In ethanol; N,N-dimethyl-formamide; acetonitrile;