Technology Process of 7-(3,5-dibromo-4-hydroxyphenethylamino)-1-tosyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one
There total 23 articles about 7-(3,5-dibromo-4-hydroxyphenethylamino)-1-tosyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
methanol;
at 20 ℃;
for 24h;
DOI:10.1039/c1ob05058c
- Guidance literature:
-
Multi-step reaction with 8 steps
1: potassium hydroxide / ethanol; N,N-dimethyl-formamide / 1.25 h / -2 °C
2: palladium on carbon; formic acid; ammonium formate / methanol / 1 h
3: 2 h / 0 °C
4: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / Reflux
5: diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate / toluene / 9 h
6: potassium tert-butylate / tetrahydrofuran / 6 h / 0 °C
7: 1,1,1,3',3',3'-hexafluoro-propanol; trimethylsilyl trifluoromethanesulfonate; bis-[(trifluoroacetoxy)iodo]benzene / water / 1 h / 0 °C
8: triethylamine / methanol / 24 h / 20 °C
With
lithium aluminium tetrahydride; formic acid; 1,1,1,3',3',3'-hexafluoro-propanol; trimethylsilyl trifluoromethanesulfonate; diphenyl phosphoryl azide; palladium on carbon; potassium tert-butylate; ammonium formate; triethylamine; triphenylphosphine; bis-[(trifluoroacetoxy)iodo]benzene; potassium hydroxide; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;
5: Mitsunobu reaction;
DOI:10.1039/c1ob05058c
- Guidance literature:
-
Multi-step reaction with 11 steps
1: K2CO3 / dimethylformamide
2: Fe, HCl / H2O
3: ICl, Na2CO3 / diethyl ether; H2O
4: 86 percent / NaHCL3 / acetone; H2O
5: 89 percent / (o-MeC6H4)3P, Et3N / Pd(OAc)2 / acetonitrile / 3 h / Heating
6: LiAlH4 / diethyl ether
7: CH2Cl2
8: NaH / dimethylformamide
9: 100 percent / H2 / Pd/C / methanol
10: 82 percent / Fremy's salt / acetone; H2O
11: 1.) TFA, 2.) NaHCO3 / 1.) CH2Cl2, 2.) EtOH
With
hydrogenchloride; lithium aluminium tetrahydride; potassiuim nitrosodisulfonate; hydrogen; Iodine monochloride; iron; sodium hydride; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid;
palladium diacetate; palladium on activated charcoal;
In
methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jo9815397
