(2'R,4''R,2E)-4''-benzyl-3''-[3-(oxiran-2'-yl)acryloyl]-oxazolidin-2''-one

Base Information

• Chemical Name: (2'R,4''R,2E)-4''-benzyl-3''-[3-(oxiran-2'-yl)acryloyl]-oxazolidin-2''-one
• CAS No.: 857058-56-1
• Molecular Formula: C₁₅H₁₅NO₄
• Molecular Weight: 273.288

Synonyms:(2'R,4''R,2E)-4''-benzyl-3''-[3-(oxiran-2'-yl)acryloyl]-oxazolidin-2''-one

Chemical Property of (2'R,4''R,2E)-4''-benzyl-3''-[3-(oxiran-2'-yl)acryloyl]-oxazolidin-2''-one

Chemical Property:

Purity/Quality:

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Technology Process of (2'R,4''R,2E)-4''-benzyl-3''-[3-(oxiran-2'-yl)acryloyl]-oxazolidin-2''-one

There total 1 articles about (2'R,4''R,2E)-4''-benzyl-3''-[3-(oxiran-2'-yl)acryloyl]-oxazolidin-2''-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(R)-4-(phenylmethyl)-2-oxazolidinone (40217-17-2,90719-32-7,120574-96-1,102029-44-7) + (2'R,2E)-3-(oxiran-2'-yl)acrylic ethyl ester (191275-36-2) → (2'R,4''R,2E)-4''-benzyl-3''-[3-(oxiran-2'-yl)acryloyl]-oxazolidin-2''-one (857058-56-1)

Guidance literature:

(2'R,2E)-3-(oxiran-2'-yl)acrylic ethyl ester; With lithium hydroxide; In 1,4-dioxane; methanol; water; at 0 ℃;

(R)-4-(phenylmethyl)-2-oxazolidinone; With pivaloyl chloride; triethylamine; lithium chloride; at 0 ℃;

DOI:10.1246/cl.2005.698

Reference yield: 76.0%

(2'R,4''R,2E)-4''-benzyl-3''-[3-(oxiran-2'-yl)acryloyl]-oxazolidin-2''-one (857058-56-1) + 3-phenyl-propionaldehyde (104-53-0) → (R)-4-Benzyl-3-[(E)-(S)-5-hydroxy-2-((R)-1-hydroxy-3-phenyl-propyl)-pent-3-enoyl]-oxazolidin-2-one + (R)-4-Benzyl-3-[(E)-(S)-5-hydroxy-2-((S)-1-hydroxy-3-phenyl-propyl)-pent-3-enoyl]-oxazolidin-2-one

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at -78 ℃; for 0.5h;

DOI:10.1246/cl.2005.698

Reference yield:

(2'R,4''R,2E)-4''-benzyl-3''-[3-(oxiran-2'-yl)acryloyl]-oxazolidin-2''-one (857058-56-1) + propionaldehyde (123-38-6) → (R)-4-Benzyl-3-[(E)-(S)-5-hydroxy-2-((R)-1-hydroxy-propyl)-pent-3-enoyl]-oxazolidin-2-one (857058-58-3) + (R)-4-Benzyl-3-[(E)-(S)-5-hydroxy-2-((S)-1-hydroxy-propyl)-pent-3-enoyl]-oxazolidin-2-one

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at -78 ℃; for 0.5h;

DOI:10.1246/cl.2005.698

upstream raw materials:

(R)-4-(phenylmethyl)-2-oxazolidinone

(2'R,2E)-3-(oxiran-2'-yl)acrylic ethyl ester

Downstream raw materials:

(R)-4-Benzyl-3-[(E)-(S)-5-hydroxy-2-((R)-1-hydroxy-propyl)-pent-3-enoyl]-oxazolidin-2-one

(R)-4-Benzyl-3-[(E)-(S)-2-((R)-1-hydroxy-propyl)-5-(2-trimethylsilanyl-ethoxymethoxy)-pent-3-enoyl]-oxazolidin-2-one

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