2-Pyridinamine,6-ethynyl-(9CI)

Base Information

• Chemical Name: 2-Pyridinamine,6-ethynyl-(9CI)
• CAS No.: 173314-98-2
• Molecular Formula: C7H6 N2
• Molecular Weight: 118.138
• Mol file: 173314-98-2.mol

Synonyms:6-Ethynyl-2-pyridinamine

Chemical Property of 2-Pyridinamine,6-ethynyl-(9CI)

Chemical Property:

• PSA: 38.91000
• LogP: 1.22630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

6-Ethynyl-2-pyridinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinamine,6-ethynyl-(9CI)

There total 4 articles about 2-Pyridinamine,6-ethynyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-amino-6-<(trimethylsilyl)ethynyl>pyridine (173314-97-1) → 6-ethynyl-pyridin-2-ylamine (173314-98-2)

Guidance literature:

With potassium hydroxide; In methanol; for 1h;

DOI:10.1021/jo3016659

Reference yield: 67.0%

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) + trimethylsilylacetylene (1066-54-2) → 6-ethynyl-pyridin-2-ylamine (173314-98-2)

Guidance literature:

2-Amino-6-bromopyridine; trimethylsilylacetylene; With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In benzene; at 50 ℃; for 7h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -20 - 0 ℃;

Reference yield:

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) → 6-ethynyl-pyridin-2-ylamine (173314-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / Et₂NH, (PPh₃)2PdCl₂, CuI / 10 h / Ambient temperature

2: 91 percent / H₂O, n-Bu₄F / tetrahydrofuran / 4 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; diethylamine; In tetrahydrofuran;

DOI:10.1021/ja00155a006

upstream raw materials:

2-amino-6-<(trimethylsilyl)ethynyl>pyridine

2-Amino-6-bromopyridine

trimethylsilylacetylene

Downstream raw materials:

6-(1-benzyl-1H-1,2,3-triazol-4-yl)pyridin-2-amine

C₄₂H₄₀BrN₇O₂

3-((6-aminopyridin-2-yl)ethynyl)-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-amine