1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl)[1,1'-biphenyl]-4-yl]-N-methyl-1H-pyrrole-2-carboxamide

Base Information

• Chemical Name: 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl)[1,1'-biphenyl]-4-yl]-N-methyl-1H-pyrrole-2-carboxamide
• CAS No.: 256512-33-1
• Molecular Formula: C₂₈H₂₆N₄O₃S
• Molecular Weight: 498.605
• Mol file: 256512-33-1.mol

Synonyms:1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl)[1,1'-biphenyl]-4-yl]-N-methyl-1H-pyrrole-2-carboxamide

Chemical Property of 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl)[1,1'-biphenyl]-4-yl]-N-methyl-1H-pyrrole-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl)[1,1'-biphenyl]-4-yl]-N-methyl-1H-pyrrole-2-carboxamide

There total 4 articles about 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl)[1,1'-biphenyl]-4-yl]-N-methyl-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

4-(2'-tert-butylaminosulfonylphenyl)aniline (193006-34-7) + 1-(3-cyanophenyl)pyrrole-2-carboxylic acid (209958-46-3) → 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl)[1,1'-biphenyl]-4-yl]-N-methyl-1H-pyrrole-2-carboxamide (256512-33-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 18h;

DOI:10.1021/jm000409z

Reference yield:

1-(3-cyanophenyl)pyrrole-2-carboxaldehyde (209958-45-2) → 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl)[1,1'-biphenyl]-4-yl]-N-methyl-1H-pyrrole-2-carboxamide (256512-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / aq. KMnO₄ / acetone / 0 - 20 °C

2: 29 percent / Et₃N; benzotriazol-1-yloxytris(N(CH₃)2)phosphonium F₆-phosphate / dimethylformamide / 18 h / 50 °C

With potassium permanganate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm000409z

Reference yield:

m-cyanoaniline (2237-30-1) → 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl)[1,1'-biphenyl]-4-yl]-N-methyl-1H-pyrrole-2-carboxamide (256512-33-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / AcOH / Heating

2: 83 percent / POCl₃ / 1,2-dichloro-ethane / 0.5 h / Heating

3: 74 percent / aq. KMnO₄ / acetone / 0 - 20 °C

4: 29 percent / Et₃N; benzotriazol-1-yloxytris(N(CH₃)2)phosphonium F₆-phosphate / dimethylformamide / 18 h / 50 °C

With potassium permanganate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; trichlorophosphate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm000409z

upstream raw materials:

4-(2'-tert-butylaminosulfonylphenyl)aniline

1-(3-cyanophenyl)pyrrole-2-carboxylic acid

1-(3-cyanophenyl)pyrrole-2-carboxaldehyde

m-cyanoaniline