4-[(E)-4-(5-fluorobenzo[b]thiophen-2-yl)-2-methyl-3-buten-2-yl]-1-triphenylmethyl-1H-imidazole

Base Information

Chemical Name:4-[(E)-4-(5-fluorobenzo[b]thiophen-2-yl)-2-methyl-3-buten-2-yl]-1-triphenylmethyl-1H-imidazole
CAS No.:698367-98-5
Molecular Formula:C₃₅H₂₉FN₂S
Molecular Weight:528.693
Hs Code.:

Synonyms:4-[(E)-4-(5-fluorobenzo[b]thiophen-2-yl)-2-methyl-3-buten-2-yl]-1-triphenylmethyl-1H-imidazole

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Chemical Property of 4-[(E)-4-(5-fluorobenzo[b]thiophen-2-yl)-2-methyl-3-buten-2-yl]-1-triphenylmethyl-1H-imidazole

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Technology Process of 4-[(E)-4-(5-fluorobenzo[b]thiophen-2-yl)-2-methyl-3-buten-2-yl]-1-triphenylmethyl-1H-imidazole

There total 8 articles about 4-[(E)-4-(5-fluorobenzo[b]thiophen-2-yl)-2-methyl-3-buten-2-yl]-1-triphenylmethyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 64464-49-9
2-methyl-2-(1-triphenylmethyl-1H-imidazol-4-yl)propanal

: 698367-92-9
diethyl (5-fluorobenzo[b]thiophen-2-yl)methylphosphonate

: 698367-98-5
4-[(E)-4-(5-fluorobenzo[b]thiophen-2-yl)-2-methyl-3-buten-2-yl]-1-triphenylmethyl-1H-imidazole

Guidance literature:: diethyl (5-fluorobenzo[b]thiophen-2-yl)methylphosphonate; With sodium hydride; In tetrahydrofuran; for 1h;

2-methyl-2-(1-triphenylmethyl-1H-imidazol-4-yl)propanal; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2004.02.007

Reference yield:

: 13771-69-2
ethyl 5-fluorobenzo[b]thiophene-2-carboxylate

: 698367-98-5
4-[(E)-4-(5-fluorobenzo[b]thiophen-2-yl)-2-methyl-3-buten-2-yl]-1-triphenylmethyl-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

2.1: 69 percent / thionyl chloride / tetrahydrofuran / 1 h / Heating

3.1: 89 percent / 3 h / 160 °C

4.1: sodium hydride / tetrahydrofuran / 1 h

4.2: 92 percent / tetrahydrofuran / 18 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sodium hydride; In tetrahydrofuran; 4.2: Horner-Emmons olefination;
DOI:10.1016/j.bmc.2004.02.007

Reference yield:

: 13771-73-8
(5-fluorobenzo[b]thiophen-2-yl)methanol

: 698367-98-5
4-[(E)-4-(5-fluorobenzo[b]thiophen-2-yl)-2-methyl-3-buten-2-yl]-1-triphenylmethyl-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 69 percent / thionyl chloride / tetrahydrofuran / 1 h / Heating

2.1: 89 percent / 3 h / 160 °C

3.1: sodium hydride / tetrahydrofuran / 1 h

3.2: 92 percent / tetrahydrofuran / 18 h / 20 °C

With thionyl chloride; sodium hydride; In tetrahydrofuran; 3.2: Horner-Emmons olefination;
DOI:10.1016/j.bmc.2004.02.007