(S)-7-(benzyloxy)-4-(4-(benzyloxy)phenyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: (S)-7-(benzyloxy)-4-(4-(benzyloxy)phenyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 96444-12-1
• Molecular Formula: C₃₁H₃₁NO₃
• Molecular Weight: 465.592
• Mol file: 96444-12-1.mol

Synonyms:(S)-7-(benzyloxy)-4-(4-(benzyloxy)phenyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property of (S)-7-(benzyloxy)-4-(4-(benzyloxy)phenyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-7-(benzyloxy)-4-(4-(benzyloxy)phenyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 7 articles about (S)-7-(benzyloxy)-4-(4-(benzyloxy)phenyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(S)-7-Benzyloxy-4-(4-benzyloxy-phenyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester (96405-83-3) → (S)-7-(benzyloxy)-4-(4-(benzyloxy)phenyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (96444-12-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1039/c39840001646

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + C29H29NO3 → (S)-7-(benzyloxy)-4-(4-(benzyloxy)phenyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (96444-12-1)

Guidance literature:

With formic acid; In tetrahydrofuran; water; at 90 ℃;

DOI:10.1002/anie.201302349

Reference yield:

(S)-3,9-Bis-benzyloxy-2-methoxy-7,12-dihydro-5H-6,12-methano-dibenzo[c,f]azocine 6-oxide (96405-80-0) → (S)-7-(benzyloxy)-4-(4-(benzyloxy)phenyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (96444-12-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / tBu-OK / 2-methyl-propan-2-ol

2: 84 percent / RhCl(Ph₃P)3 / toluene / Heating

3: 86 percent / LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; RhCl(PPh₃)3; potassium tert-butylate; In tetrahydrofuran; toluene; tert-butyl alcohol;

DOI:10.1039/c39840001646

upstream raw materials:

(S)-7-Benzyloxy-4-(4-benzyloxy-phenyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester

(S)-3,9-Bis-benzyloxy-2-methoxy-7,12-dihydro-5H-6,12-methano-dibenzo[c,f]azocine 6-oxide

(R)-7-Benzyloxy-4-(4-benzyloxy-2-formyl-phenyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester

3,9-dibenzyloxy-2-methoxytetrahydro-6,12-methanodibenzazocine

Downstream raw materials:

(4S)-4-(4-hydroxyphenyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol