2-(3-Bromophenoxy)ethylamine

Base Information

• Chemical Name: 2-(3-Bromophenoxy)ethylamine
• CAS No.: 926211-83-8
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 216.077
• ChEMBL ID: CHEMBL4943175
• DSSTox Substance ID: DTXSID40588150
• Wikidata: Q82480662
• Mol file: 926211-83-8.mol

Synonyms:926211-83-8;2-(3-bromophenoxy)ethylamine;2-(3-bromophenoxy)ethanamine;2-(3-Bromo-phenoxy)-ethylamine;2-(3-Bromophenoxy)ethan-1-amine;[2-(3-bromophenoxy)ethyl]amine hydrochloride;MFCD09042556;SCHEMBL2754673;CHEMBL4943175;DTXSID40588150;AKOS000126906;MCULE-8392696674;SB77020;AM804556;CS-12184;SY039347;DB-121597;CS-0018040;EN300-58514

Chemical Property of 2-(3-Bromophenoxy)ethylamine

Chemical Property:

• Boiling Point: 282.8±20.0 °C(Predicted)
• PKA: 8.41±0.10(Predicted)
• Density: 1.442±0.06 g/cm3(Predicted)
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 214.99458
• Heavy Atom Count: 11
• Complexity: 110

Purity/Quality:

97% ^*data from raw suppliers

[2-(3-Bromophenoxy)ethyl]amine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Br)OCCN

Technology Process of 2-(3-Bromophenoxy)ethylamine

There total 5 articles about 2-(3-Bromophenoxy)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-(2-(3-Bromophenoxy)ethyl)phthalimide (938642-05-8) → 2-(3-bromophenoxy)ethanamine (926211-83-8)

Guidance literature:

With hydrazine; In ethanol; water; for 1.5h; Heating / reflux;

Reference yield:

3-bromophenoxyacetonitrile (951918-24-4) → 2-(3-bromophenoxy)ethanamine (926211-83-8)

Guidance literature:

With potassium borohydride; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 12h; Sealed tube;

Reference yield:

3-Bromophenol (591-20-8) → 2-(3-bromophenoxy)ethanamine (926211-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C / Cooling with ice

2: hydrazine hydrate / ethanol / 1.5 h / Reflux; Inert atmosphere

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

upstream raw materials:

N-(2-(3-Bromophenoxy)ethyl)phthalimide

3-Bromophenol

2-(3-bromo-phenoxy)-ethanol

2-(3-bromophenoxy)ethyl methanesulfonate

Downstream raw materials:

C₁₀H₉BrF₃NO₂

2,2,2-trifluoro-N-(2-(3-(5-hydroxypent-1-ynyl)phenoxy)ethyl)acetamide

2,2,2-trifluoro-N-(2-(3-((1-hydroxycyclopentyl)ethynyl)phenoxy)ethyl)acetamide

2,2,2-trifluoro-N-(2-(3-(3-hydroxy-3-methylbut-1-ynyl)phenoxy)ethyl)acetamide