acrylic acid (1S,3S,4R)-3-benzyloxy-2,2-dimethyl-4-vinylcyclobutyl ester

Base Information

Chemical Name:acrylic acid (1S,3S,4R)-3-benzyloxy-2,2-dimethyl-4-vinylcyclobutyl ester
CAS No.:952101-24-5
Molecular Formula:C₁₈H₂₂O₃
Molecular Weight:286.371
Hs Code.:

Synonyms:acrylic acid (1S,3S,4R)-3-benzyloxy-2,2-dimethyl-4-vinylcyclobutyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of acrylic acid (1S,3S,4R)-3-benzyloxy-2,2-dimethyl-4-vinylcyclobutyl ester

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Technology Process of acrylic acid (1S,3S,4R)-3-benzyloxy-2,2-dimethyl-4-vinylcyclobutyl ester

There total 2 articles about acrylic acid (1S,3S,4R)-3-benzyloxy-2,2-dimethyl-4-vinylcyclobutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 895532-66-8
(1S,3S,4R)-3-benzyloxy-2,2-dimethyl-4-vinylcyclobutanol

: 814-68-6,25189-84-8
acryloyl chloride

: 952101-24-5
acrylic acid (1S,3S,4R)-3-benzyloxy-2,2-dimethyl-4-vinylcyclobutyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 8.5h;
DOI:10.1021/jo070861r

Reference yield:

: (4R,5R)-4-benzyloxy-2-methoxy-3,3-dimethyl-5-vinyltetrahydrofuran

: 952101-24-5
acrylic acid (1S,3S,4R)-3-benzyloxy-2,2-dimethyl-4-vinylcyclobutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / BF₃*OEt₂; n-butyllithium / Cp₂ZrCl₂ / tetrahydrofuran; hexane / -78 - 20 °C

2: 92 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 8.5 h

With dmap; n-butyllithium; boron trifluoride diethyl etherate; triethylamine; zirconocene dichloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo070861r

Reference yield: 94.0%

: 952101-24-5
acrylic acid (1S,3S,4R)-3-benzyloxy-2,2-dimethyl-4-vinylcyclobutyl ester

: 952092-33-0
(1S,6S,7S)-7-benzyloxy-8,8-dimethyl-2-oxabicyclo[4.2.0]oct-4-en-3-one

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 18h;
DOI:10.1021/jo070861r