5-azido-2,3,5-trideoxy-6-O-(3,5-difluorophenyl)-2-methyl-L-idono-1,4-lactone

Base Information

Chemical Name:5-azido-2,3,5-trideoxy-6-O-(3,5-difluorophenyl)-2-methyl-L-idono-1,4-lactone
CAS No.:1067648-54-7
Molecular Formula:C₁₃H₁₃F₂N₃O₃
Molecular Weight:297.261
Hs Code.:

Synonyms:5-azido-2,3,5-trideoxy-6-O-(3,5-difluorophenyl)-2-methyl-L-idono-1,4-lactone

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Chemical Property of 5-azido-2,3,5-trideoxy-6-O-(3,5-difluorophenyl)-2-methyl-L-idono-1,4-lactone

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Technology Process of 5-azido-2,3,5-trideoxy-6-O-(3,5-difluorophenyl)-2-methyl-L-idono-1,4-lactone

There total 2 articles about 5-azido-2,3,5-trideoxy-6-O-(3,5-difluorophenyl)-2-methyl-L-idono-1,4-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1067648-53-6
C₁₃H₁₄F₂O₄

: 1067648-55-8
5-azido-2,3,5-trideoxy-6-O-(3,5-difluorophenyl)-2-methyl-L-gulono-1,4-lactone

: 1067648-54-7
5-azido-2,3,5-trideoxy-6-O-(3,5-difluorophenyl)-2-methyl-L-idono-1,4-lactone

Guidance literature:: C₁₃H₁₄F₂O₄; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -15 ℃; for 0.5h;

With diphenyl phosphoryl azide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 1067648-52-5
5,6-anhydro-2,3-dideoxy-2-methyl-D-glucono-1,4-lactone

: 1067648-54-7
5-azido-2,3,5-trideoxy-6-O-(3,5-difluorophenyl)-2-methyl-L-idono-1,4-lactone

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 110 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / -15 - 0 °C

2.2: 0 - 20 °C

With di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2009.11.013

Reference yield: 70.0%

: 1067648-54-7
5-azido-2,3,5-trideoxy-6-O-(3,5-difluorophenyl)-2-methyl-L-idono-1,4-lactone

: 106566-02-3,120369-25-7,144902-31-8
L-valine benzylamide

: 1067648-56-9
(2R,4S,5S)-5-azido-6-(3,5-difluorophenoxy)-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

Guidance literature:: With 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 96h; Reflux;
DOI:10.1016/j.ejmech.2009.11.013