Carbamic acid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl

Base Information

Chemical Name:Carbamic acid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl
CAS No.:172720-97-7
Molecular Formula:C₁₁H₁₉NO₃
Molecular Weight:213.277
Hs Code.:
Mol file:172720-97-7.mol

Synonyms:Carbamicacid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl ester, trans-(9CI)

Suppliers and Price of Carbamic acid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rel-N-[(1R,4R)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]carbamicAcid1,1-DimethylethylEster
25mg
$ 250.00

TRC
rel-N-[(1R,4R)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]carbamicAcid1,1-DimethylethylEster
10mg
$ 140.00

Total 1 raw suppliers

Chemical Property of Carbamic acid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl

Chemical Property:

PSA：58.56000
LogP:1.83900

Purity/Quality:: rel-N-[(1R,4R)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]carbamicAcid1,1-DimethylethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses rel-N-[(1R,4R)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]carbamic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of the HIV reverse transcriptase inhibitor ziagen.

Technology Process of Carbamic acid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl

There total 91 articles about Carbamic acid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 168960-19-8,287717-44-6
(1R,4S)-1-amino-4-(hydroxymethyl)-2-cyclopentene hydrochloride

: 168960-18-7,172720-97-7
(1R,4S)-N-(tert-Butyloxycarbonyl)-1-amino-4-(hydroxymethyl)-2-cyclopentene

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In methanol; for 4h;
DOI:10.1021/jo00119a044

Reference yield: 97.0%

: 151792-53-9
tert-butyl (1R,4S)-(-)-3-oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate

: 168960-18-7,172720-97-7
(1R,4S)-N-(tert-Butyloxycarbonyl)-1-amino-4-(hydroxymethyl)-2-cyclopentene

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;
DOI:10.1021/ja050732x

Reference yield: 88.0%

: 34619-03-9
tert-butyldicarbonate

: 130931-83-8
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one

: 168960-18-7,172720-97-7
(1R,4S)-N-(tert-Butyloxycarbonyl)-1-amino-4-(hydroxymethyl)-2-cyclopentene

Guidance literature:: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one; With methanesulfonic acid; In tetrahydrofuran; water; at 34 - 44 ℃; for 2.75h; Heating / reflux;

With lithium aluminium tetrahydride; In tetrahydrofuran; for 18.5h; Heating / reflux;

tert-butyldicarbonate; With sodium fluoride; more than 3 stages;