1-(4-((E)-1-(2,6-dimethylmorpholinocarbamoyl)propen-2-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Base Information

Chemical Name:1-(4-((E)-1-(2,6-dimethylmorpholinocarbamoyl)propen-2-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
CAS No.:1598408-40-2
Molecular Formula:C₂₄H₂₅ClF₃N₃O₃
Molecular Weight:495.929
Hs Code.:

Synonyms:1-(4-((E)-1-(2,6-dimethylmorpholinocarbamoyl)propen-2-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

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Chemical Property of 1-(4-((E)-1-(2,6-dimethylmorpholinocarbamoyl)propen-2-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

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Technology Process of 1-(4-((E)-1-(2,6-dimethylmorpholinocarbamoyl)propen-2-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

There total 6 articles about 1-(4-((E)-1-(2,6-dimethylmorpholinocarbamoyl)propen-2-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

: 1598408-61-7
C₁₆H₂₂N₂O₂

: 327-78-6
4-chloro-3-(trifluoromethyl)phenyl isocyanate

: 1598408-40-2
1-(4-((E)-1-(2,6-dimethylmorpholinocarbamoyl)propen-2-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.03.020

Reference yield:

: 1598408-77-5
C₁₆H₂₀N₂O₄

: 1598408-40-2
1-(4-((E)-1-(2,6-dimethylmorpholinocarbamoyl)propen-2-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: tin(ll) chloride; hydrogenchloride / ethanol; water / 4 h / Reflux

2: dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; tin(ll) chloride; In ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2014.03.020

Reference yield:

: (E)-3-(4-nitrophenyl)but-2-enoyl chloride

: 1598408-40-2
1-(4-((E)-1-(2,6-dimethylmorpholinocarbamoyl)propen-2-yl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 8 h / 0 - 20 °C

2: tin(ll) chloride; hydrogenchloride / ethanol; water / 4 h / Reflux

3: dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; tin(ll) chloride; In ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2014.03.020