3-(5-bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole

Base Information

• Chemical Name: 3-(5-bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole
• CAS No.: 1163300-01-3
• Molecular Formula: C₁₈H₁₁BrN₄OS
• Molecular Weight: 411.282
• Mol file: 1163300-01-3.mol

Synonyms:3-(5-bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole

Chemical Property of 3-(5-bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(5-bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole

There total 1 articles about 3-(5-bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole (1163299-95-3) → 3-(5-bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole (1163300-01-3)

Guidance literature:

3-(6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole; With bromine; sodium acetate; acetic acid; at 20 ℃;

With ammonia; In water;

DOI:10.1016/j.ejmech.2008.12.019

Reference yield: 84.0%

3-(5-bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole (1163300-01-3) + thiophenol (108-98-5) → 3-(6-phenyl-5-phenylsulfanylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole

Guidance literature:

thiophenol; With sodium ethanolate; In ethanol; at 20 ℃; for 2h;

3-(5-bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole; In ethanol; for 5h; Reflux;

DOI:10.1080/10426507.2015.1012196

Reference yield:

3-(5-bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole (1163300-01-3) + thiophenol (108-98-5) → 3-([5-benzenesulfonyl-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl]methyl)benzo[d]isoxazole

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium ethanolate / ethanol / 2 h / 20 °C

1.2: 5 h / Reflux

2.1: acetic acid; dihydrogen peroxide / 48 h / 20 °C

With dihydrogen peroxide; sodium ethanolate; acetic acid; In ethanol;

DOI:10.1080/10426507.2015.1012196

upstream raw materials:

3-(6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylmethyl)benzo[d]isoxazole