2-{N-[(5-chloro-2-methoxyphenyl)sulfonyl]-N-(2-trifluoromethylallyl)amino}-N-(3,4-diifluorobenzyl)pent-4-enamide

Base Information

Chemical Name:2-{N-[(5-chloro-2-methoxyphenyl)sulfonyl]-N-(2-trifluoromethylallyl)amino}-N-(3,4-diifluorobenzyl)pent-4-enamide
CAS No.:913563-92-5
Molecular Formula:C₂₃H₂₂ClF₅N₂O₄S
Molecular Weight:552.95
Hs Code.:

Synonyms:2-{N-[(5-chloro-2-methoxyphenyl)sulfonyl]-N-(2-trifluoromethylallyl)amino}-N-(3,4-diifluorobenzyl)pent-4-enamide

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Chemical Property of 2-{N-[(5-chloro-2-methoxyphenyl)sulfonyl]-N-(2-trifluoromethylallyl)amino}-N-(3,4-diifluorobenzyl)pent-4-enamide

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Technology Process of 2-{N-[(5-chloro-2-methoxyphenyl)sulfonyl]-N-(2-trifluoromethylallyl)amino}-N-(3,4-diifluorobenzyl)pent-4-enamide

There total 4 articles about 2-{N-[(5-chloro-2-methoxyphenyl)sulfonyl]-N-(2-trifluoromethylallyl)amino}-N-(3,4-diifluorobenzyl)pent-4-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 885679-09-4
2-{[(5-chloro-2-methoxyphenyl)sulfonyl]amino}-N-(3,4-difluorobenzyl)pent-4-enamide

: 693826-80-1
toluene-4-sulfonic acid 2-trifluoromethylallyl ester

: 913563-92-5
2-{N-[(5-chloro-2-methoxyphenyl)sulfonyl]-N-(2-trifluoromethylallyl)amino}-N-(3,4-diifluorobenzyl)pent-4-enamide

Guidance literature:: 2-{[(5-chloro-2-methoxyphenyl)sulfonyl]amino}-N-(3,4-difluorobenzyl)pent-4-enamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

toluene-4-sulfonic acid 2-trifluoromethylallyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jo060893z

Reference yield:

: 885679-07-2
2-([(5-chloro-2-methoxyphenyl)sulfonyl]amino)pent-4-enoic acid

: 913563-92-5
2-{N-[(5-chloro-2-methoxyphenyl)sulfonyl]-N-(2-trifluoromethylallyl)amino}-N-(3,4-diifluorobenzyl)pent-4-enamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: HOBt; EDCI / CH₂Cl₂ / 1 h / 20 °C

1.2: 87 percent / CH₂Cl₂ / 12 h / 20 °C

2.1: NaH / dimethylformamide / 0.25 h / 20 °C

2.2: 60 percent / dimethylformamide / 12 h / 20 °C

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo060893z

Reference yield:

: 1069-48-3,7685-44-1
rac-allylglycine

: 913563-92-5
2-{N-[(5-chloro-2-methoxyphenyl)sulfonyl]-N-(2-trifluoromethylallyl)amino}-N-(3,4-diifluorobenzyl)pent-4-enamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Me₃SiCl / CH₂Cl₂ / 2 h / Heating

1.2: Et₃N / CH₂Cl₂ / 1 h / 20 °C

2.1: HOBt; EDCI / CH₂Cl₂ / 1 h / 20 °C

2.2: 87 percent / CH₂Cl₂ / 12 h / 20 °C

3.1: NaH / dimethylformamide / 0.25 h / 20 °C

3.2: 60 percent / dimethylformamide / 12 h / 20 °C

With chloro-trimethyl-silane; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo060893z