2-Chloro-3-cyano-4'-(3',4'-dimethoxyphenylethylamino)pyridine

Base Information

• Chemical Name: 2-Chloro-3-cyano-4'-(3',4'-dimethoxyphenylethylamino)pyridine
• CAS No.: 104803-03-4
• Molecular Formula: C₁₆H₁₆ClN₃O₂
• Molecular Weight: 317.775
• Mol file: 104803-03-4.mol

Synonyms:2-Chloro-3-cyano-4'-(3',4'-dimethoxyphenylethylamino)pyridine

Chemical Property of 2-Chloro-3-cyano-4'-(3',4'-dimethoxyphenylethylamino)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3-cyano-4'-(3',4'-dimethoxyphenylethylamino)pyridine

There total 1 articles about 2-Chloro-3-cyano-4'-(3',4'-dimethoxyphenylethylamino)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.2%

4-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile → 2-Chloro-3-cyano-4'-(3',4'-dimethoxyphenylethylamino)pyridine (104803-03-4)

Guidance literature:

With 2,3-Dimethylaniline; trichlorophosphate; for 2h; Heating;

DOI:10.1007/BF00758561

Reference yield: 88.0%

2-Chloro-3-cyano-4'-(3',4'-dimethoxyphenylethylamino)pyridine (104803-03-4) → 4-homoveratrylamino-3-cyano-2-aminopyridine (104802-90-6)

Guidance literature:

With ammonia; at 220 - 240 ℃; for 9h;

DOI:10.1007/BF00776332

Reference yield:

2-Chloro-3-cyano-4'-(3',4'-dimethoxyphenylethylamino)pyridine (104803-03-4) → 2-(3'-Isopropylamino-2'-hydroxyisopropoxy)-3-cyano-4-<β-(3',4'-dimethoxyphenyl)ethylamino>pyridine dihydrochloride (106000-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / dibenzo-18-crown-6 / toluene / Heating

2: 1 N aq. HCl / toluene / 50 °C / pH 3.0

With hydrogenchloride; potassium hydroxide; dibenzo-18-crown-6; In toluene;

DOI:10.1007/BF00758561

Downstream raw materials:

4-homoveratrylamino-3-cyano-2-aminopyridine

4-homoveratrylamino-3-cyano-2-pyridine

2-(3'-Isopropylamino-2'-hydroxyisopropoxy)-3-cyano-4-<β-(3',4'-dimethoxyphenyl)ethylamino>pyridine dihydrochloride