2-(3,4-dichloro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide

Base Information

• Chemical Name: 2-(3,4-dichloro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide
• CAS No.: 619254-30-7
• Molecular Formula: C₂₄H₂₈Cl₂N₂O₃
• Molecular Weight: 463.404
• Mol file: 619254-30-7.mol

Synonyms:2-(3,4-dichloro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide

Chemical Property of 2-(3,4-dichloro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-dichloro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide

There total 2 articles about 2-(3,4-dichloro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R,S)-2-(3,4-dichloro-phenyl)-pent-4-enoyl chloride (463936-45-0) + 4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenylamine hydrochloride → 2-(3,4-dichloro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide (619254-30-7)

Guidance literature:

N,N-dimethyl-formamide; In dichloromethane; at 110 ℃; for 2h;

Reference yield:

(R,S)-2-(3,4-dichloro-phenyl)-pent-4-enoyl chloride (463936-45-0) + 4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenylamine (170229-92-2) → 2-(3,4-dichloro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide (619254-30-7)

Guidance literature:

With TEA; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2006.05.034

Reference yield:

2-(3,4-dichloro-phenyl)-pent-4-enoic acid [4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide (619254-30-7) → C24H30Cl2N2O5

Guidance literature:

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In acetone; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2006.05.034

upstream raw materials:

(R,S)-2-(3,4-dichloro-phenyl)-pent-4-enoyl chloride

4-methoxy-3-(2-pyrrolidin-1-yl-ethoxy)-phenylamine