[(2-bromo-pyridin-3-ylmethylene)-amino]diphenylacetic acid allyl ester

Base Information

• Chemical Name: [(2-bromo-pyridin-3-ylmethylene)-amino]diphenylacetic acid allyl ester
• CAS No.: 1086429-67-5
• Molecular Formula: C₂₃H₁₉BrN₂O₂
• Molecular Weight: 435.32
• Mol file: 1086429-67-5.mol

Synonyms:[(2-bromo-pyridin-3-ylmethylene)-amino]diphenylacetic acid allyl ester

Chemical Property of [(2-bromo-pyridin-3-ylmethylene)-amino]diphenylacetic acid allyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of [(2-bromo-pyridin-3-ylmethylene)-amino]diphenylacetic acid allyl ester

There total 1 articles about [(2-bromo-pyridin-3-ylmethylene)-amino]diphenylacetic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

allyl 2,2-diphenylglycinate (946164-43-8) + 2-bromopyridine-3-carboxaldehyde (128071-75-0) → [(2-bromo-pyridin-3-ylmethylene)-amino]diphenylacetic acid allyl ester (1086429-67-5)

Guidance literature:

In benzene; for 23h; Reflux; Inert atmosphere;

DOI:10.1021/ol801986m

Reference yield: 74.0%

[(2-bromo-pyridin-3-ylmethylene)-amino]diphenylacetic acid allyl ester (1086429-67-5) → C22H18N2 (1086429-73-3)

Guidance literature:

[(2-bromo-pyridin-3-ylmethylene)-amino]diphenylacetic acid allyl ester; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

With triethylamine; In N,N-dimethyl-formamide; at 150 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/ol801986m

Reference yield:

[(2-bromo-pyridin-3-ylmethylene)-amino]diphenylacetic acid allyl ester (1086429-67-5) → (S)-1,1-diphenyl-N-(1-(2-bromopyridine-3-yl)but-3-en-1-yl)methanimine + (R)-1,1-diphenyl-N-(1-(2-bromopyridine-3-yl)but-3-en-1-yl)methanimine

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R,R)-1,1'-bis{(R)-4,5-dihydro-3H-dinaphtho[1,2-c:2',1'-e]-phosphepino}ferrocene; In dimethyl sulfoxide; at 25 ℃; Overall yield = 85 %; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol502693r

upstream raw materials:

allyl 2,2-diphenylglycinate

2-bromopyridine-3-carboxaldehyde

Downstream raw materials:

C₂₂H₁₈N₂