(E)-N-benzyl-2-styrylbenzamide

Base Information

• Chemical Name: (E)-N-benzyl-2-styrylbenzamide
• CAS No.: 86769-98-4
• Molecular Formula: C₂₂H₁₉NO
• Molecular Weight: 313.399
• Mol file: 86769-98-4.mol

Synonyms:(E)-N-benzyl-2-styrylbenzamide

Chemical Property of (E)-N-benzyl-2-styrylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-benzyl-2-styrylbenzamide

There total 5 articles about (E)-N-benzyl-2-styrylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N-benzylbenzamide (1485-70-7) → (E)-N-benzyl-2-styrylbenzamide (86769-98-4)

Guidance literature:

With silver hexafluoroantimonate; C₄₆H₄₀Cl₄N₂O₈Rh₂; copper(II) acetate monohydrate; In 1,2-dichloro-ethane; at 60 ℃; for 16h; Schlenk technique;

DOI:10.1021/acs.joc.8b02875

Reference yield:

C15H11ClO (907174-66-7) + benzylamine (100-46-9) → (E)-N-benzyl-2-styrylbenzamide (86769-98-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1002/adsc.201700369

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → (E)-N-benzyl-2-styrylbenzamide (86769-98-4)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 5 h / 100 °C

2: lithium hydroxide / tetrahydrofuran; water; methanol / 12 h / 70 °C

3: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 60 °C

4: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With thionyl chloride; palladium diacetate; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/adsc.201700369

upstream raw materials:

trans-stilbene-2-carbonyl chloride

benzylamine

C₁₅H₁₁ClO

styrene

Downstream raw materials:

(Z)-2-benzyl-3-benzylidene-2,3-dihydro-1H-isoindolin-1-one

N,9-dibenzyl-8-azabicyclo<4.3.0>nona-1(6),2,4-trien-7-one