(S)-2-((1H-imidazol-1-yl)methyl)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)oxazole-4-carboxamide

Base Information

Chemical Name:(S)-2-((1H-imidazol-1-yl)methyl)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)oxazole-4-carboxamide
CAS No.:1297542-18-7
Molecular Formula:C₂₁H₁₈ClN₇O₂
Molecular Weight:435.873
Hs Code.:

Synonyms:(S)-2-((1H-imidazol-1-yl)methyl)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)oxazole-4-carboxamide

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Chemical Property of (S)-2-((1H-imidazol-1-yl)methyl)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)oxazole-4-carboxamide

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Technology Process of (S)-2-((1H-imidazol-1-yl)methyl)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)oxazole-4-carboxamide

There total 8 articles about (S)-2-((1H-imidazol-1-yl)methyl)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)oxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.23%

: 288-32-4
1H-imidazole

: 1297542-22-3
(S)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(chloromethyl)oxazole-4-carboxamide

: 1297542-18-7
(S)-2-((1H-imidazol-1-yl)methyl)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)oxazole-4-carboxamide

Guidance literature:: 1H-imidazole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

(S)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(chloromethyl)oxazole-4-carboxamide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 154607-01-9
4-bromo-2-chlorobenzonitrile

: 1297542-18-7
(S)-2-((1H-imidazol-1-yl)methyl)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)oxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 2.5 h / 35 °C

2.1: hydrogenchloride / ethanol / 1 h / 30 °C / Inert atmosphere

3.1: sodium hydroxide / water; methanol / 2 h / 25 °C / Inert atmosphere

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

4.2: 20 h / 20 °C

5.1: dicyclohexyl-carbodiimide / dichloromethane / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

6.2: 0 - 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; sodium hydride; sodium carbonate; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 208465-72-9
methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate

: 1297542-18-7
(S)-2-((1H-imidazol-1-yl)methyl)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)oxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

1.2: pH 1.5 / Acidic conditions

2.1: dicyclohexyl-carbodiimide / dichloromethane / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C

With sodium hydride; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;