(E)-(3-(3-(3-hydroxy-4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Base Information

Chemical Name:(E)-(3-(3-(3-hydroxy-4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate
CAS No.:1333242-21-9
Molecular Formula:C₃₀H₂₆N₂O₈S
Molecular Weight:574.611
Hs Code.:

Synonyms:(E)-(3-(3-(3-hydroxy-4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

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Chemical Property of (E)-(3-(3-(3-hydroxy-4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

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Technology Process of (E)-(3-(3-(3-hydroxy-4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

There total 4 articles about (E)-(3-(3-(3-hydroxy-4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1333242-44-6
(5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

: 537-73-5
trans-3-hydroxy-4-methoxycinnamic acid

: 1333242-21-9
(E)-(3-(3-(3-hydroxy-4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: With toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 1333242-42-4
tert-butyl 1-((benzylsulfonyloxy)methyl)-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

: 1333242-21-9
(E)-(3-(3-(3-hydroxy-4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: methoxybenzene; trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

2: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 20 °C

With toluene-4-sulfonic acid; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 193225-63-7
3-(tert-butoxycarbonyl)-1-(hydroxymethyl)-5-nitro-1,2-dihydro-3H-benzindole

: 1333242-21-9
(E)-(3-(3-(3-hydroxy-4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.33 h / 0 °C

2: methoxybenzene; trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 20 °C

With toluene-4-sulfonic acid; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2011.06.073