trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)-N'-(2,2,2-trifluoroethyl)cyclohexane-1,4-diamine

Base Information

Chemical Name:trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)-N'-(2,2,2-trifluoroethyl)cyclohexane-1,4-diamine
CAS No.:1607589-92-3
Molecular Formula:C₁₅H₁₇F₃N₄O₂S
Molecular Weight:374.387
Hs Code.:

Synonyms:trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)-N'-(2,2,2-trifluoroethyl)cyclohexane-1,4-diamine

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Chemical Property of trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)-N'-(2,2,2-trifluoroethyl)cyclohexane-1,4-diamine

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Technology Process of trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)-N'-(2,2,2-trifluoroethyl)cyclohexane-1,4-diamine

There total 4 articles about trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)-N'-(2,2,2-trifluoroethyl)cyclohexane-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 6226-25-1
2,2,2-trifluoroethyl trifluoromethanesulphonate

: 1607589-91-2
trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)cyclohexane-1,4-diamine

: 1607589-92-3
trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)-N'-(2,2,2-trifluoroethyl)cyclohexane-1,4-diamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607589-92-3
trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)-N'-(2,2,2-trifluoroethyl)cyclohexane-1,4-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With tetrabutylammonium nitrate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 110651-92-8
7-chloro-6-nitrothieno[3,2-b]pyridine

: 1607589-92-3
trans-N-(6-nitrothieno[3,2-b]pyridin-7-yl)-N'-(2,2,2-trifluoroethyl)cyclohexane-1,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;