ethyl 3-(4-nitrophenyl)-2,3-dioxopropanoate

Base Information

• Chemical Name: ethyl 3-(4-nitrophenyl)-2,3-dioxopropanoate
• CAS No.: 54458-38-7
• Molecular Formula: C₁₁H₉NO₆
• Molecular Weight: 251.196
• Mol file: 54458-38-7.mol

Synonyms:ethyl 3-(4-nitrophenyl)-2,3-dioxopropanoate

Chemical Property of ethyl 3-(4-nitrophenyl)-2,3-dioxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 3-(4-nitrophenyl)-2,3-dioxopropanoate

There total 2 articles about ethyl 3-(4-nitrophenyl)-2,3-dioxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-nitrobenzoylacetate (838-57-3) → ethyl 3-(4-nitrophenyl)-2,3-dioxopropanoate (54458-38-7)

Guidance literature:

With selenium(IV) oxide;

DOI:10.1002/hlca.19740570736

Reference yield:

ethyl 4-nitrobenzoylacetate (838-57-3) → ethyl 3-(4-nitrophenyl)-2,3-dioxopropanoate (54458-38-7) + ethyl 2,2-dihydroxy-3-(4-nitrophenyl)-3-oxopropanoate

Guidance literature:

With triphenylphosphine hydrobromide; dimethyl sulfoxide; at 50 ℃; for 4h; Overall yield = 77 %; Overall yield = 0.0436 g; chemoselective reaction; Inert atmosphere;

DOI:10.1021/acs.joc.5b00846

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethyl 3-(4-nitrophenyl)-2,3-dioxopropanoate (54458-38-7) → ethyl 5-(4-nitrophenyl)-3H-imidazole-4-carboxylate

Guidance literature:

With ammonium acetate; In acetic acid; at 20 - 65 ℃; for 4h;

upstream raw materials:

ethyl 4-nitrobenzoylacetate