isopropyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate

Base Information

Chemical Name:isopropyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate
CAS No.:1427330-89-9
Molecular Formula:C₂₄H₂₁F₄NO₃
Molecular Weight:447.429
Hs Code.:

Synonyms:isopropyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate

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Chemical Property of isopropyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate

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Technology Process of isopropyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate

There total 9 articles about isopropyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.4%

: 1427330-86-6
2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy] acetic acid

: 67-63-0,8013-70-5
isopropyl alcohol

: 1427330-89-9
isopropyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate

Guidance literature:: With sulfuric acid; at 20 ℃;

Reference yield:

: 768-35-4
3-fluorophenylboronic acid

: 1427330-89-9
isopropyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2: thionyl chloride / 1 h / 65 °C / Inert atmosphere

3: triethylamine / dichloromethane / 3 h / 20 °C

4: borane-THF / tetrahydrofuran / 2 h / 0 - 60 °C

5: lithium hydroxide monohydrate; water / tetrahydrofuran / 60 °C

6: sulfuric acid / 20 °C / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; borane-THF; lithium hydroxide monohydrate; sulfuric acid; water; sodium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1427330-96-8
ethyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)benzoyl]amino]phenoxy]acetate

: 1427330-89-9
isopropyl 2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 2 h / 0 - 60 °C

2: lithium hydroxide monohydrate; water / tetrahydrofuran / 60 °C

3: sulfuric acid / 20 °C / Reflux

With borane-THF; lithium hydroxide monohydrate; sulfuric acid; water; In tetrahydrofuran;