(R)-benzyl 3-((2-((benzoyloxycarbonyl)(3,3-dimethyl-2-oxobutyl)amino)phenyl) (cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

Base Information

Chemical Name:(R)-benzyl 3-((2-((benzoyloxycarbonyl)(3,3-dimethyl-2-oxobutyl)amino)phenyl) (cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate
CAS No.:1246926-33-9
Molecular Formula:C₃₈H₄₄F₃N₃O₆
Molecular Weight:695.779
Hs Code.:

Synonyms:(R)-benzyl 3-((2-((benzoyloxycarbonyl)(3,3-dimethyl-2-oxobutyl)amino)phenyl) (cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

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Chemical Property of (R)-benzyl 3-((2-((benzoyloxycarbonyl)(3,3-dimethyl-2-oxobutyl)amino)phenyl) (cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

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Technology Process of (R)-benzyl 3-((2-((benzoyloxycarbonyl)(3,3-dimethyl-2-oxobutyl)amino)phenyl) (cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

There total 5 articles about (R)-benzyl 3-((2-((benzoyloxycarbonyl)(3,3-dimethyl-2-oxobutyl)amino)phenyl) (cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74628-31-2
N-1-cyclohexylbenzene-1,2-diamine

: 1246926-33-9
(R)-benzyl 3-((2-((benzoyloxycarbonyl)(3,3-dimethyl-2-oxobutyl)amino)phenyl) (cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / ethyl acetate; N,N-dimethyl-formamide; water / 3 h / 40 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / Inert atmosphere; Cooling with ice

2.2: 0.5 h

3.1: toluene / 4 h / Inert atmosphere; Reflux

With sodium hydride; triethylamine; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1246926-28-2
benzyl 2-(cyclohexylamino)phenyl (3,3-dimethyl-2-oxobutyl) carbamate

: 1246926-29-3
(R)-benzyl 1-(2,2,2-trifluoroacetyl)aziridine-2-carboxylate

: 1246926-33-9
(R)-benzyl 3-((2-((benzoyloxycarbonyl)(3,3-dimethyl-2-oxobutyl)amino)phenyl) (cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

Guidance literature:: In toluene; for 4h; Inert atmosphere; Reflux;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1246926-33-9
(R)-benzyl 3-((2-((benzoyloxycarbonyl)(3,3-dimethyl-2-oxobutyl)amino)phenyl) (cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / ethyl acetate; N,N-dimethyl-formamide; water / 3 h / 40 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / Inert atmosphere; Cooling with ice

2.2: 0.5 h

3.1: toluene / 4 h / Inert atmosphere; Reflux

With sodium hydride; triethylamine; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; toluene;