(1RS,3RS,5SR,7SR)-8-(diphenylphosphoryl)-4-oxa-8-azatricyclo[5.1.0.0^3,5]octane

Base Information

• Chemical Name: (1RS,3RS,5SR,7SR)-8-(diphenylphosphoryl)-4-oxa-8-azatricyclo[5.1.0.0^3,5]octane
• CAS No.: 254888-52-3
• Molecular Formula: C₁₈H₁₈NO₂P
• Molecular Weight: 311.32
• Mol file: 254888-52-3.mol

Synonyms:(1RS,3RS,5SR,7SR)-8-(diphenylphosphoryl)-4-oxa-8-azatricyclo[5.1.0.0^3,5]octane

Chemical Property of (1RS,3RS,5SR,7SR)-8-(diphenylphosphoryl)-4-oxa-8-azatricyclo[5.1.0.0^3,5]octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1RS,3RS,5SR,7SR)-8-(diphenylphosphoryl)-4-oxa-8-azatricyclo[5.1.0.0^3,5]octane

There total 7 articles about (1RS,3RS,5SR,7SR)-8-(diphenylphosphoryl)-4-oxa-8-azatricyclo[5.1.0.0^3,5]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(1R,6S)-7-(Diphenyl-phosphinoyl)-7-aza-bicyclo[4.1.0]hept-3-ene → (1RS,3SR,5RS,7SR)-8-(diphenylphosphoryl)-4-oxa-8-azatricyclo[5.1.0.03,5]octane (254888-51-2) + (1RS,3RS,5SR,7SR)-8-(diphenylphosphoryl)-4-oxa-8-azatricyclo[5.1.0.03,5]octane (254888-52-3)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 14h;

DOI:10.1016/S0040-4039(99)01741-4

Reference yield: 81.0%

7-(diphenylphosphoryl)-7-azabicyclo[4.1.0]hept-3-ene (254888-50-1) → (1RS,3SR,5RS,7SR)-8-(diphenylphosphoryl)-4-oxa-8-azatricyclo[5.1.0.03,5]octane (254888-51-2) + (1RS,3RS,5SR,7SR)-8-(diphenylphosphoryl)-4-oxa-8-azatricyclo[5.1.0.03,5]octane (254888-52-3)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 16h; Further Variations:; Reagents; Solvents; Temperatures; time; Product distribution;

DOI:10.1039/b210608f

Reference yield:

(1S,3S,5R,7R)-4-Oxa-8-aza-tricyclo[5.1.0.03,5]octane (220826-69-7) + Diphenylphosphinic chloride (1499-21-4) → (1RS,3RS,5SR,7SR)-8-(diphenylphosphoryl)-4-oxa-8-azatricyclo[5.1.0.03,5]octane (254888-52-3)

Guidance literature:

With dmap; triethylamine; at 20 ℃; for 20h;

DOI:10.1016/S0040-4039(99)01741-4

upstream raw materials:

(1S,3S,5R,7R)-4-Oxa-8-aza-tricyclo[5.1.0.0^3,5]octane

Diphenylphosphinic chloride

7-(diphenylphosphoryl)-7-azabicyclo[4.1.0]hept-3-ene

4,5-epoxy-cyclohexene

Downstream raw materials:

(1R,3S,6R)-7-diphenylphosphoryl-7-azabicyclo[4.1.0]hept-4-en-3-ol