1,1-dimethylethyl 6-{[(2-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazol-4-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 6-{[(2-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazol-4-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate
CAS No.:1200399-62-7
Molecular Formula:C₂₆H₂₆F₃N₃O₃S
Molecular Weight:517.572
Hs Code.:

Synonyms:1,1-dimethylethyl 6-{[(2-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazol-4-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

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Chemical Property of 1,1-dimethylethyl 6-{[(2-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazol-4-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

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Technology Process of 1,1-dimethylethyl 6-{[(2-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazol-4-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

There total 2 articles about 1,1-dimethylethyl 6-{[(2-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazol-4-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1200399-61-6
2-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazol-4-amine

: 170097-67-3
2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

: 1200399-62-7
1,1-dimethylethyl 6-{[(2-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazol-4-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 168h;

Reference yield:

: 1200399-60-5
1,1-dimethylethyl (2-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazol-4-yl)carbamate

: 1200399-62-7
1,1-dimethylethyl 6-{[(2-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazol-4-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 168 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; ethyl acetate;