Acetic acid (4S,5S,6R)-5-(tert-butyl-diphenyl-silanyloxy)-6-(2,6-dioxo-piperidin-4-yl)-[1,3]dioxan-4-ylmethyl ester

Base Information

Chemical Name:Acetic acid (4S,5S,6R)-5-(tert-butyl-diphenyl-silanyloxy)-6-(2,6-dioxo-piperidin-4-yl)-[1,3]dioxan-4-ylmethyl ester
CAS No.:102615-82-7
Molecular Formula:C₂₈H₃₅NO₇Si
Molecular Weight:525.674
Hs Code.:

Synonyms:Acetic acid (4S,5S,6R)-5-(tert-butyl-diphenyl-silanyloxy)-6-(2,6-dioxo-piperidin-4-yl)-[1,3]dioxan-4-ylmethyl ester

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Chemical Property of Acetic acid (4S,5S,6R)-5-(tert-butyl-diphenyl-silanyloxy)-6-(2,6-dioxo-piperidin-4-yl)-[1,3]dioxan-4-ylmethyl ester

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Technology Process of Acetic acid (4S,5S,6R)-5-(tert-butyl-diphenyl-silanyloxy)-6-(2,6-dioxo-piperidin-4-yl)-[1,3]dioxan-4-ylmethyl ester

There total 5 articles about Acetic acid (4S,5S,6R)-5-(tert-butyl-diphenyl-silanyloxy)-6-(2,6-dioxo-piperidin-4-yl)-[1,3]dioxan-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 92886-86-7
tert-butyldiphenylsilyl triflate

: 102615-81-6
Acetic acid (4S,5S,6R)-6-(2,6-dioxo-piperidin-4-yl)-5-hydroxy-[1,3]dioxan-4-ylmethyl ester

: 102615-82-7
Acetic acid (4S,5S,6R)-5-(tert-butyl-diphenyl-silanyloxy)-6-(2,6-dioxo-piperidin-4-yl)-[1,3]dioxan-4-ylmethyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane;
DOI:10.1021/jo00363a051

Reference yield:

: 93125-65-6
(4R,4aS,8aS)-4-(Tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl)-piperidine-2,6-dione

: 102615-82-7
Acetic acid (4S,5S,6R)-5-(tert-butyl-diphenyl-silanyloxy)-6-(2,6-dioxo-piperidin-4-yl)-[1,3]dioxan-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / trifluoroacetic anhydride (TFAA) / 6 h / 22 °C

2: 100 percent / 2,6-lutidine / CH₂Cl₂

With 2,6-dimethylpyridine; trifluoroacetic anhydride; In dichloromethane;
DOI:10.1021/jo00363a051

Reference yield:

: 102615-79-2
(E)-(4R,4aS,8aS)-3-(Tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl)-acrylic acid ethyl ester

: 102615-82-7
Acetic acid (4S,5S,6R)-5-(tert-butyl-diphenyl-silanyloxy)-6-(2,6-dioxo-piperidin-4-yl)-[1,3]dioxan-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent

2: 1.) ammonium hydroxide / 1.) 50 deg C, 24 h, 2.) 155-210 deg C, 50 min

3: 87 percent / trifluoroacetic anhydride (TFAA) / 6 h / 22 °C

4: 100 percent / 2,6-lutidine / CH₂Cl₂

With 2,6-dimethylpyridine; ammonium hydroxide; trifluoroacetic anhydride; In dichloromethane;
DOI:10.1021/jo00363a051