(R)-3-(N-Benzyloxycarbonylpyrrolidin-2-ylmethyl)-5-(methylaminosulfonylmethyl)-1H-indole

Base Information

Chemical Name:(R)-3-(N-Benzyloxycarbonylpyrrolidin-2-ylmethyl)-5-(methylaminosulfonylmethyl)-1H-indole
CAS No.:143321-82-8
Molecular Formula:C₂₃H₂₇N₃O₄S
Molecular Weight:441.551
Hs Code.:

Synonyms:(R)-3-(N-Benzyloxycarbonylpyrrolidin-2-ylmethyl)-5-(methylaminosulfonylmethyl)-1H-indole

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Chemical Property of (R)-3-(N-Benzyloxycarbonylpyrrolidin-2-ylmethyl)-5-(methylaminosulfonylmethyl)-1H-indole

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Technology Process of (R)-3-(N-Benzyloxycarbonylpyrrolidin-2-ylmethyl)-5-(methylaminosulfonylmethyl)-1H-indole

There total 9 articles about (R)-3-(N-Benzyloxycarbonylpyrrolidin-2-ylmethyl)-5-(methylaminosulfonylmethyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 146727-86-8
(R)-2-{(E)-3-[(2-Bromo-4-methylsulfamoylmethyl-phenyl)-(2,2,2-trifluoro-acetyl)-amino]-propenyl}-pyrrolidine-1-carboxylic acid benzyl ester

: 143321-82-8
(R)-3-(N-Benzyloxycarbonylpyrrolidin-2-ylmethyl)-5-(methylaminosulfonylmethyl)-1H-indole

Guidance literature:: With triethylamine; palladium diacetate; In N,N-dimethyl-formamide; Heating;
DOI:10.1016/S0040-4039(00)74703-4

Reference yield:

: 68832-13-3
D-prolinol

: 143321-82-8
(R)-3-(N-Benzyloxycarbonylpyrrolidin-2-ylmethyl)-5-(methylaminosulfonylmethyl)-1H-indole

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / Et₃N

2: 1.) DMSO, (CF₃CO)2O / 1.) -78 deg C

3: 73 percent

4: 54 percent / diisobutylaluminum hydride (DIBAH) / -78 °C

5: 67 percent / PPh₃, diethylazodicarboxylate (DEAD)

6: 81 percent / Et₃N / Pd(OAc)2 / dimethylformamide / Heating

With diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; trifluoroacetic anhydride; diethylazodicarboxylate; palladium diacetate; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74703-4

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 143321-82-8
(R)-3-(N-Benzyloxycarbonylpyrrolidin-2-ylmethyl)-5-(methylaminosulfonylmethyl)-1H-indole

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / Et₃N

2: 1.) DMSO, (CF₃CO)2O / 1.) -78 deg C

3: 73 percent

4: 54 percent / diisobutylaluminum hydride (DIBAH) / -78 °C

5: 67 percent / PPh₃, diethylazodicarboxylate (DEAD)

6: 81 percent / Et₃N / Pd(OAc)2 / dimethylformamide / Heating

With diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; trifluoroacetic anhydride; diethylazodicarboxylate; palladium diacetate; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74703-4