N-(4,4-dimethyl-pentyl)-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

Base Information

Chemical Name:N-(4,4-dimethyl-pentyl)-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide
CAS No.:1472103-81-3
Molecular Formula:C₂₁H₃₄N₂O₄S
Molecular Weight:410.578
Hs Code.:

Synonyms:N-(4,4-dimethyl-pentyl)-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

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Chemical Property of N-(4,4-dimethyl-pentyl)-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

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Technology Process of N-(4,4-dimethyl-pentyl)-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

There total 10 articles about N-(4,4-dimethyl-pentyl)-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1472104-24-7
2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

: methanesulfonic acid 4,4-dimethylpentan-1-ol ester

: 1472103-81-3
N-(4,4-dimethyl-pentyl)-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

Guidance literature:: 2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 23 ℃; for 0.5h;

methanesulfonic acid 4,4-dimethylpentan-1-ol ester; In tetrahydrofuran; mineral oil; at 23 ℃; for 16h;

Reference yield: 23.0%

: methanesulfonic acid 4,4-dimethyl-pentan-1-ol ester

: 1472104-24-7
2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

: 1472103-81-3
N-(4,4-dimethyl-pentyl)-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

Guidance literature:: 2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide; With N-[(4-chlorophenyl)-methyl]-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide; sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.5h;

methanesulfonic acid 4,4-dimethyl-pentan-1-ol ester; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 16h;

Reference yield:

: 917-92-0
3,3-Dimethylbut-1-yne

: 1472103-81-3
N-(4,4-dimethyl-pentyl)-2-(ethylsulfonyl)-6-methyl-4-morpholin-4-yl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / diethyl ether; hexane / 1.25 h / -78 - -40 °C

1.2: 3 h / -78 - 23 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 16 h

3.1: triethylamine / dichloromethane / 1.5 h / 0 - 23 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 23 °C

4.2: 16 h / 23 °C

With n-butyllithium; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; In diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;