(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(5-iodooxazol-2-yl)methanone

Base Information

Chemical Name:(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(5-iodooxazol-2-yl)methanone
CAS No.:1289561-06-3
Molecular Formula:C₂₁H₁₈INO₃
Molecular Weight:459.283
Hs Code.:

Synonyms:(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(5-iodooxazol-2-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(5-iodooxazol-2-yl)methanone

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Technology Process of (6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(5-iodooxazol-2-yl)methanone

There total 13 articles about (6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(5-iodooxazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1289563-56-9
(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(5-iodooxazol-2-yl)methanol

: 1289561-06-3
(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(5-iodooxazol-2-yl)methanone

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm101597x

Reference yield: 84.0%

: 1289561-06-3
(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(5-iodooxazol-2-yl)methanone

Guidance literature:

Reference yield:

: 65844-44-2
methyl 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

: 1289561-06-3
(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(5-iodooxazol-2-yl)methanone

Guidance literature:: Multi-step reaction with 8 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4.1: borane-THF / tetrahydrofuran / 1 h / 20 °C

4.2: 0.67 h / -78 °C

4.3: 2 h / -78 °C

5.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

6.2: 0.08 h

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

8.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; borane-THF; tetrabutyl ammonium fluoride; Dess-Martin periodane; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Mitsunobu alkylation;
DOI:10.1021/jm101597x