(R)-4-((R)-1-(7-(3,5-dimethoxy-4-(2-morpholinoethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

Base Information

Chemical Name:(R)-4-((R)-1-(7-(3,5-dimethoxy-4-(2-morpholinoethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one
CAS No.:1319737-94-4
Molecular Formula:C₂₈H₃₄N₄O₆
Molecular Weight:522.601
Hs Code.:

Synonyms:(R)-4-((R)-1-(7-(3,5-dimethoxy-4-(2-morpholinoethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

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Chemical Property of (R)-4-((R)-1-(7-(3,5-dimethoxy-4-(2-morpholinoethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

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Technology Process of (R)-4-((R)-1-(7-(3,5-dimethoxy-4-(2-morpholinoethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

There total 6 articles about (R)-4-((R)-1-(7-(3,5-dimethoxy-4-(2-morpholinoethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1319736-55-4
(R)-4-((R)-1-hydroxyethyl)pyrrolidine-2-one

: 1319737-57-9
C₂₂H₂₄ClN₃O₄

: 1319737-94-4
(R)-4-((R)-1-(7-(3,5-dimethoxy-4-(2-morpholinoethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

Guidance literature:: (R)-4-((R)-1-hydroxyethyl)pyrrolidine-2-one; With sodium hydride; In N,N-dimethyl acetamide; at 20 ℃; for 0.25h;

C₂₂H₂₄ClN₃O₄; In N,N-dimethyl acetamide; at 70 ℃; for 2h;

Reference yield:

: 99735-43-0,96449-93-3,99735-44-1
(3R)-1-((R)-1-phenylethyl)-5-oxo-3-pyrrolidinecarboxylic acid

: 1319737-94-4
(R)-4-((R)-1-(7-(3,5-dimethoxy-4-(2-morpholinoethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 0 - 20 °C

2.1: diethyl ether; tetrahydrofuran / -10 °C / Inert atmosphere

3.1: lithium dihydrido borata-bicyclo[3.3.0]nonane / dichloromethane; tetrahydrofuran / -50 - -30 °C / Inert atmosphere

3.2: 20 °C / Aqueous phosphate buffer

4.1: trifluoroacetic acid / 1.5 h / 150 °C / Microwave irradiation

5.1: sodium hydride / N,N-dimethyl acetamide / 0.25 h / 20 °C

5.2: 2 h / 70 °C

With 4-methyl-morpholine; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; lithium dihydrido borata-bicyclo[3.3.0]nonane; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 146511-96-8
(R)-4-acetyl-1-((R)-1-phenylethyl)pyrrolidine-2-one

: 1319737-94-4
(R)-4-((R)-1-(7-(3,5-dimethoxy-4-(2-morpholinoethoxy)phenyl)-1,6-naphthyridine-5-yloxy)ethyl)pyrrolidine-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium dihydrido borata-bicyclo[3.3.0]nonane / dichloromethane; tetrahydrofuran / -50 - -30 °C / Inert atmosphere

1.2: 20 °C / Aqueous phosphate buffer

2.1: trifluoroacetic acid / 1.5 h / 150 °C / Microwave irradiation

3.1: sodium hydride / N,N-dimethyl acetamide / 0.25 h / 20 °C

3.2: 2 h / 70 °C

With sodium hydride; trifluoroacetic acid; lithium dihydrido borata-bicyclo[3.3.0]nonane; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;