toluene-4-thiosulfonic acid S-(2-tert-butyl-4-ethylsulfamoyloxy-5-methyl-phenyl) ester

Base Information

Chemical Name:toluene-4-thiosulfonic acid S-(2-tert-butyl-4-ethylsulfamoyloxy-5-methyl-phenyl) ester
CAS No.:207737-21-1
Molecular Formula:C₂₀H₂₇NO₅S₃
Molecular Weight:457.636
Hs Code.:

Synonyms:toluene-4-thiosulfonic acid S-(2-tert-butyl-4-ethylsulfamoyloxy-5-methyl-phenyl) ester

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Chemical Property of toluene-4-thiosulfonic acid S-(2-tert-butyl-4-ethylsulfamoyloxy-5-methyl-phenyl) ester

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Technology Process of toluene-4-thiosulfonic acid S-(2-tert-butyl-4-ethylsulfamoyloxy-5-methyl-phenyl) ester

There total 6 articles about toluene-4-thiosulfonic acid S-(2-tert-butyl-4-ethylsulfamoyloxy-5-methyl-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 16548-07-5
ethylsulfamoyl chloride

: 207737-17-5
toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxy-5-methylphenyl) ester

: 207737-21-1
toluene-4-thiosulfonic acid S-(2-tert-butyl-4-ethylsulfamoyloxy-5-methyl-phenyl) ester

Guidance literature:: With triethylamine; In diethyl ether; for 0.5h;
DOI:10.1021/jm990281p

Reference yield:

: 62559-08-4
4-tert-butyl-2-nitrotoluene

: 207737-21-1
toluene-4-thiosulfonic acid S-(2-tert-butyl-4-ethylsulfamoyloxy-5-methyl-phenyl) ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Raney Ni / methanol / 15 h / 35 °C / 2689.24 Torr

2: aq. NaNO₂; aq. 15percent H₂SO₄ / 0.5 h / 70 °C

3: Br₂; NaBr / methanol / 0.5 h / 5 - 40 °C

4: 79 percent / dithiothreitol; 0.02M KH₂PO₄ / ethanol / 4 h / Heating

5: 91 percent / pyridine / CCl₄

6: 98 percent / Et₃N / diethyl ether / 0.5 h

With pyridine; potassium dihydrogenphosphate; hydrogen; bromine; triethylamine; sodium bromide; sodium nitrite; diothiothreitol; nickel; In methanol; tetrachloromethane; diethyl ether; ethanol; 1: Reduction / 2: Diazotization / 3: Substitution / 4: Hydrolysis / 5: Tosylation / 6: Sulfonylation;
DOI:10.1021/jm990281p

Reference yield:

: 5781-02-2
5-(tert-butyl)-2-methylphenol

: 207737-21-1
toluene-4-thiosulfonic acid S-(2-tert-butyl-4-ethylsulfamoyloxy-5-methyl-phenyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: Br₂; NaBr / methanol / 0.5 h / 5 - 40 °C

2: 79 percent / dithiothreitol; 0.02M KH₂PO₄ / ethanol / 4 h / Heating

3: 91 percent / pyridine / CCl₄

4: 98 percent / Et₃N / diethyl ether / 0.5 h

With pyridine; potassium dihydrogenphosphate; bromine; triethylamine; sodium bromide; diothiothreitol; In methanol; tetrachloromethane; diethyl ether; ethanol; 1: Substitution / 2: Hydrolysis / 3: Tosylation / 4: Sulfonylation;
DOI:10.1021/jm990281p