L-Alanine, 3-amino-2-methyl- (9CI)

Base Information

• Chemical Name: L-Alanine, 3-amino-2-methyl- (9CI)
• CAS No.: 170384-23-3
• Molecular Formula: C4H10 N2 O2
• Molecular Weight: 118.1344
• Mol file: 170384-23-3.mol

Synonyms:L-Alanine, 3-amino-2-methyl- (9CI)

Chemical Property of L-Alanine, 3-amino-2-methyl- (9CI)

Chemical Property:

• Melting Point: 200-201 °C (decomp)
• Boiling Point: 293.4±30.0 °C(Predicted)
• PKA: 1.80±0.10(Predicted)
• PSA: 89.34000
• Density: 1.222±0.06 g/cm3(Predicted)
• LogP: 0.14770

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Alanine, 3-amino-2-methyl- (9CI)

There total 4 articles about L-Alanine, 3-amino-2-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

di(tert-butyl) 1-[(2R,5S)-1-benzoyl-1,2,3,4,5,6-hexahydro-3,5-dimethyl-2-(1-methylethyl)-4-oxopyrimidin-5-yl]hydrazine-1,2-dicarboxylate → (+)-(2S)-2,3-Diamino-2-methylpropanoic acid (170384-23-3,170554-69-5)

Guidance literature:

di(tert-butyl) 1-[(2R,5S)-1-benzoyl-1,2,3,4,5,6-hexahydro-3,5-dimethyl-2-(1-methylethyl)-4-oxopyrimidin-5-yl]hydrazine-1,2-dicarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With hydrogen; nickel; In methanol; dichloromethane; at 20 ℃; for 24h; under 51754.1 Torr;

With hydrogenchloride; In water; at 90 ℃;

DOI:10.1002/hlca.200490073

Reference yield: 84.4%

(S)-2,3-bis(benzamido)-2-methylpropanoic acid → (+)-(2S)-2,3-Diamino-2-methylpropanoic acid (170384-23-3,170554-69-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 100 ℃; for 18h;

DOI:10.1002/hlca.19950780317

Reference yield:

(S)-3-Amino-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propionic acid → (+)-(2S)-2,3-Diamino-2-methylpropanoic acid (170384-23-3,170554-69-5)

Guidance literature:

With ammonia; lithium; In tetrahydrofuran; tert-butyl alcohol; at -78 ℃; for 0.166667h; Yield given;

DOI:10.1021/jo00074a016

Refernces

• 1、 Castellanos, Elena,Reyes-Rangel, Gloria,Juaristi, Eusebio. "Diastereoselective Electrophilic Amination of Chiral 1-Benzoyl-2,3,5,6-tetrahydro-3-methyl-2-(1-methylethyl)pyrimidin-4(1H)-one for the Asymmetric Syntheses of α-Substituted α,β-Diaminopropanoic Acids)". . p. 1016 - 1024. Retrieved 2007/10/03.
• 2、 Colson, Pierre-Jean,Hegedus, Louis S.. "Asymmetric Synthesis of α-Alkyl-α-amino Acids from Chromium-Carbene-Complex-Derived β-Lactams". . p. 5918 - 5924. Retrieved 2007/10/02.