methyl (2S)-allyl(4-methylphenylsulfonyl)amino(phenyl)acetate

Base Information

• Chemical Name: methyl (2S)-allyl(4-methylphenylsulfonyl)amino(phenyl)acetate
• CAS No.: 1213779-01-1
• Molecular Formula: C₁₉H₂₁NO₄S
• Molecular Weight: 359.446
• Mol file: 1213779-01-1.mol

Synonyms:methyl (2S)-allyl(4-methylphenylsulfonyl)amino(phenyl)acetate

Chemical Property of methyl (2S)-allyl(4-methylphenylsulfonyl)amino(phenyl)acetate

Chemical Property:

Purity/Quality:

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Technology Process of methyl (2S)-allyl(4-methylphenylsulfonyl)amino(phenyl)acetate

There total 1 articles about methyl (2S)-allyl(4-methylphenylsulfonyl)amino(phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl (2S)-(allylamino)(phenyl)acetate (934991-64-7) + p-toluenesulfonyl chloride (98-59-9) → methyl (2S)-allyl(4-methylphenylsulfonyl)amino(phenyl)acetate (1213779-01-1)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1055/s-0029-1218359

Reference yield: 63.0%

methyl (2S)-allyl(4-methylphenylsulfonyl)amino(phenyl)acetate (1213779-01-1) → (1S,2S)-3-(4-methylphenylsulfonyl)-2-phenyl-3-azabicyclo[3.1.0]hexan-1-ol (1213779-02-2) + (1R,2S)-3-(4-methylphenylsulfonyl)-2-phenyl-3-azabicyclo[3.1.0]hexan-1-ol (1213778-99-4)

Guidance literature:

With titanium(IV) isopropylate; isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; optical yield given as %de;

DOI:10.1055/s-0029-1218359

upstream raw materials:

methyl (2S)-(allylamino)(phenyl)acetate

p-toluenesulfonyl chloride

Downstream raw materials:

(1S,2S)-3-(4-methylphenylsulfonyl)-2-phenyl-3-azabicyclo[3.1.0]hexan-1-ol

(1R,2S)-3-(4-methylphenylsulfonyl)-2-phenyl-3-azabicyclo[3.1.0]hexan-1-ol