(R)-N-(4-(3-fluorobenzyloxy)benzyl)-2-aminopropionamide hydrochloride

Base Information

Chemical Name:(R)-N-(4-(3-fluorobenzyloxy)benzyl)-2-aminopropionamide hydrochloride
CAS No.:1334604-86-2
Molecular Formula:C₁₇H₁₉FN₂O₂*ClH
Molecular Weight:338.809
Hs Code.:

Synonyms:(R)-N-(4-(3-fluorobenzyloxy)benzyl)-2-aminopropionamide hydrochloride

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Chemical Property of (R)-N-(4-(3-fluorobenzyloxy)benzyl)-2-aminopropionamide hydrochloride

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Technology Process of (R)-N-(4-(3-fluorobenzyloxy)benzyl)-2-aminopropionamide hydrochloride

There total 2 articles about (R)-N-(4-(3-fluorobenzyloxy)benzyl)-2-aminopropionamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1334605-11-6
(R)-N-(4-(3-fluorobenzyloxy)benzyl)-2-t-butoxycarbonylaminopropionamide

: 1334604-86-2
(R)-N-(4-(3-fluorobenzyloxy)benzyl)-2-aminopropionamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;
DOI:10.1021/jm200759t

Reference yield:

: 849805-95-4
(4-((3-fluorobenzyl)oxy)phenyl)methanamine

: 1334604-86-2
(R)-N-(4-(3-fluorobenzyloxy)benzyl)-2-aminopropionamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm200759t