[5-(3-{4-[(2-ethyl-5-fluorophenyl)carbonyl]piperidin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

Base Information

Chemical Name:[5-(3-{4-[(2-ethyl-5-fluorophenyl)carbonyl]piperidin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid
CAS No.:1241896-62-7
Molecular Formula:C₂₀H₂₁FN₆O₄
Molecular Weight:428.423
Hs Code.:

Synonyms:[5-(3-{4-[(2-ethyl-5-fluorophenyl)carbonyl]piperidin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

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Chemical Property of [5-(3-{4-[(2-ethyl-5-fluorophenyl)carbonyl]piperidin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

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Technology Process of [5-(3-{4-[(2-ethyl-5-fluorophenyl)carbonyl]piperidin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

There total 8 articles about [5-(3-{4-[(2-ethyl-5-fluorophenyl)carbonyl]piperidin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59142-68-6
2-bromo-4-fluorobenzaldehyde

: 1241896-62-7
[5-(3-{4-[(2-ethyl-5-fluorophenyl)carbonyl]piperidin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethyl acetate; diethyl ether / 2.33 h / 0 °C / Inert atmosphere

2.1: chloro-trimethyl-silane; sodium iodide / hexane / 20 °C / Inert atmosphere

3.1: tert.-butyl lithium / ethyl acetate; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

3.2: 1.17 h / -78 - 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

5.1: sodium hydrogencarbonate / tert-butyl alcohol / 26 h / 110 °C / Sealed tube

6.1: sodium hydrogencarbonate; ammonium cerium (IV) nitrate / tetrahydrofuran / 1.33 h

7.1: formic acid / 0.5 h / 100 °C

With hydrogenchloride; chloro-trimethyl-silane; formic acid; ammonium cerium (IV) nitrate; tert.-butyl lithium; sodium hydrogencarbonate; sodium iodide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; ethyl acetate; tert-butyl alcohol;

Reference yield:

: 1241898-90-7
tert-butyl [5-(3-{4-[(2-ethyl-5-fluorophenyl)carbonyl]piperidin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetate

: 1241896-62-7
[5-(3-{4-[(2-ethyl-5-fluorophenyl)carbonyl]piperidin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

Guidance literature:: With formic acid; at 100 ℃; for 0.5h;

Reference yield:

: 261711-20-0
1-(2-bromo-4-fluorophenyl)ethan-1-ol

: 1241896-62-7
[5-(3-{4-[(2-ethyl-5-fluorophenyl)carbonyl]piperidin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: chloro-trimethyl-silane; sodium iodide / hexane / 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / ethyl acetate; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

2.2: 1.17 h / -78 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.1: sodium hydrogencarbonate / tert-butyl alcohol / 26 h / 110 °C / Sealed tube

5.1: sodium hydrogencarbonate; ammonium cerium (IV) nitrate / tetrahydrofuran / 1.33 h

6.1: formic acid / 0.5 h / 100 °C

With hydrogenchloride; chloro-trimethyl-silane; formic acid; ammonium cerium (IV) nitrate; tert.-butyl lithium; sodium hydrogencarbonate; sodium iodide; In tetrahydrofuran; 1,4-dioxane; hexane; ethyl acetate; tert-butyl alcohol;