N-[5-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-2-(4-fluoro-3-trifluoromethyl-phenyl)-acetamide

Base Information

Chemical Name:N-[5-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-2-(4-fluoro-3-trifluoromethyl-phenyl)-acetamide
CAS No.:1381925-13-8
Molecular Formula:C₂₀H₁₇ClF₄N₂O₃
Molecular Weight:444.813
Hs Code.:

Synonyms:N-[5-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-2-(4-fluoro-3-trifluoromethyl-phenyl)-acetamide

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Chemical Property of N-[5-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-2-(4-fluoro-3-trifluoromethyl-phenyl)-acetamide

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Technology Process of N-[5-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-2-(4-fluoro-3-trifluoromethyl-phenyl)-acetamide

There total 6 articles about N-[5-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-2-(4-fluoro-3-trifluoromethyl-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 473721-14-1
2-[4-fluoro-3-(trifluoromethyl)phenyl]acetyl chloride

: 1381925-28-5
4-amino-5-chloro-2-((R)-2-hydroxy-1-methylethyl)-2,3-dihydro-isoindol-1-one

: 1381925-13-8
N-[5-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-2-(4-fluoro-3-trifluoromethyl-phenyl)-acetamide

Guidance literature:: 2-[4-fluoro-3-(trifluoromethyl)phenyl]acetyl chloride; 4-amino-5-chloro-2-((R)-2-hydroxy-1-methylethyl)-2,3-dihydro-isoindol-1-one; With dodecyltrimethylammonium bromide; sodium hydrogencarbonate; In tetrahydrofuran; for 3h; Reflux;

With potassium carbonate; In methanol; water; at 20 ℃; for 18h;

Reference yield:

: 98475-07-1
2-bromomethyl-3-nitro-benzoic acid methyl ester

: 1381925-13-8
N-[5-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-2-(4-fluoro-3-trifluoromethyl-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 24 h / 20 - 50 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C / 2585.81 Torr

3.1: N-chloro-succinimide / acetonitrile / 1.33 h / 75 °C

4.1: sodium hydrogencarbonate; dodecyltrimethylammonium bromide / tetrahydrofuran / 3 h / Reflux

4.2: 18 h / 20 °C

With N-chloro-succinimide; hydrogen; dodecyltrimethylammonium bromide; sodium hydrogencarbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; toluene; acetonitrile;

Reference yield:

: 59382-59-1
2-methyl-3-nitro-benzoic acid methyl ester

: 1381925-13-8
N-[5-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-2-(4-fluoro-3-trifluoromethyl-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 18 h / Reflux

2.1: toluene / 24 h / 20 - 50 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C / 2585.81 Torr

4.1: N-chloro-succinimide / acetonitrile / 1.33 h / 75 °C

5.1: sodium hydrogencarbonate; dodecyltrimethylammonium bromide / tetrahydrofuran / 3 h / Reflux

5.2: 18 h / 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; hydrogen; dodecyltrimethylammonium bromide; sodium hydrogencarbonate; dibenzoyl peroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane; toluene; acetonitrile;