Technology Process of ethyl 3-<2-(3-isopropylpyridyl)>cinnamoate
There total 5 articles about ethyl 3-<2-(3-isopropylpyridyl)>cinnamoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
1,4-dioxane;
at 120 ℃;
for 3.5h;
DOI:10.3987/COM-94-6720
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) Mg, 2.) ZnCl2, (Ph3P)4Pd / 1.) THF, reflux, 1 h, 2.) THF, overnight
2: 85 percent / H2 / 10percent Pd/C / tetrahydrofuran / 17 h / Ambient temperature
3: 55 percent / CuCl2, t-butyl nitrite / acetonitrile / 17 h / Ambient temperature
4: 100 percent / DBU / dioxane / 3.5 h / 120 °C
With
tetrakis(triphenylphosphine) palladium(0); tert.-butylnitrite; hydrogen; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride; zinc(II) chloride;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; acetonitrile;
DOI:10.3987/COM-94-6720
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) Mg, 2.) ZnCl2, (Ph3P)4Pd / 1.) THF, reflux, 1 h, 2.) THF, overnight
2: 85 percent / H2 / 10percent Pd/C / tetrahydrofuran / 17 h / Ambient temperature
3: 55 percent / CuCl2, t-butyl nitrite / acetonitrile / 17 h / Ambient temperature
4: 100 percent / DBU / dioxane / 3.5 h / 120 °C
With
tetrakis(triphenylphosphine) palladium(0); tert.-butylnitrite; hydrogen; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride; zinc(II) chloride;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; acetonitrile;
DOI:10.3987/COM-94-6720
